Connelly S - Search Results

1

Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.

Choi S, Connelly S, Reixach N, Wilson IA, Kelly JW. Choi S, et al. Among authors: connelly s. Nat Chem Biol. 2010 Feb;6(2):133-9. doi: 10.1038/nchembio.281. Nat Chem Biol. 2010. PMID: 20081815 Free PMC article.

2

Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.

Johnson SM, Connelly S, Wilson IA, Kelly JW. Johnson SM, et al. Among authors: connelly s. J Med Chem. 2008 Jan 24;51(2):260-70. doi: 10.1021/jm0708735. Epub 2007 Dec 21. J Med Chem. 2008. PMID: 18095641

3

Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.

Johnson SM, Connelly S, Wilson IA, Kelly JW. Johnson SM, et al. Among authors: connelly s. J Med Chem. 2008 Oct 23;51(20):6348-58. doi: 10.1021/jm800435s. Epub 2008 Sep 24. J Med Chem. 2008. PMID: 18811132 Free PMC article.

4

Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.

Johnson SM, Connelly S, Wilson IA, Kelly JW. Johnson SM, et al. Among authors: connelly s. J Med Chem. 2009 Feb 26;52(4):1115-25. doi: 10.1021/jm801347s. J Med Chem. 2009. PMID: 19191553 Free PMC article.

5

A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.

Choi S, Reixach N, Connelly S, Johnson SM, Wilson IA, Kelly JW. Choi S, et al. Among authors: connelly s. J Am Chem Soc. 2010 Feb 3;132(4):1359-70. doi: 10.1021/ja908562q. J Am Chem Soc. 2010. PMID: 20043671 Free PMC article.

6

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses.

Connelly S, Choi S, Johnson SM, Kelly JW, Wilson IA. Connelly S, et al. Curr Opin Struct Biol. 2010 Feb;20(1):54-62. doi: 10.1016/j.sbi.2009.12.009. Epub 2010 Feb 3. Curr Opin Struct Biol. 2010. PMID: 20133122 Free PMC article. Review.

7

The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug.

Johnson SM, Connelly S, Fearns C, Powers ET, Kelly JW. Johnson SM, et al. Among authors: connelly s. J Mol Biol. 2012 Aug 10;421(2-3):185-203. doi: 10.1016/j.jmb.2011.12.060. Epub 2012 Jan 5. J Mol Biol. 2012. PMID: 22244854 Free PMC article. Review.

8

Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate.

Grimster NP, Connelly S, Baranczak A, Dong J, Krasnova LB, Sharpless KB, Powers ET, Wilson IA, Kelly JW. Grimster NP, et al. Among authors: connelly s. J Am Chem Soc. 2013 Apr 17;135(15):5656-68. doi: 10.1021/ja311729d. Epub 2013 Feb 14. J Am Chem Soc. 2013. PMID: 23350654 Free PMC article.

9

Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors.

Myung N, Connelly S, Kim B, Park SJ, Wilson IA, Kelly JW, Choi S. Myung N, et al. Among authors: connelly s. Chem Commun (Camb). 2013 Oct 14;49(80):9188-9190. doi: 10.1039/c3cc44667k. Epub 2013 Aug 29. Chem Commun (Camb). 2013. PMID: 23989101 Free PMC article.

10

Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging--what we know and what we need to learn.

Baranczak A, Connelly S, Liu Y, Choi S, Grimster NP, Powers ET, Wilson IA, Kelly JW. Baranczak A, et al. Among authors: connelly s. Biopolymers. 2014 May;101(5):484-95. doi: 10.1002/bip.22407. Biopolymers. 2014. PMID: 24105107 Free PMC article.

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