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MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2.
Hsu CH, Chan D, Greggio E, Saha S, Guillily MD, Ferree A, Raghavan K, Shen GC, Segal L, Ryu H, Cookson MR, Wolozin B. Hsu CH, et al. Among authors: saha s. J Neurochem. 2010 Mar;112(6):1593-604. doi: 10.1111/j.1471-4159.2010.06568.x. Epub 2010 Jan 7. J Neurochem. 2010. PMID: 20067578 Free PMC article.
LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans.
Saha S, Guillily MD, Ferree A, Lanceta J, Chan D, Ghosh J, Hsu CH, Segal L, Raghavan K, Matsumoto K, Hisamoto N, Kuwahara T, Iwatsubo T, Moore L, Goldstein L, Cookson M, Wolozin B. Saha S, et al. J Neurosci. 2009 Jul 22;29(29):9210-8. doi: 10.1523/JNEUROSCI.2281-09.2009. J Neurosci. 2009. PMID: 19625511 Free PMC article.
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer P, Yue Z, Bandopadhyay R, Glicksman MA, Moore DJ, Collins JJ, Wolozin B. Dusonchet J, et al. Among authors: saha s. Hum Mol Genet. 2014 Sep 15;23(18):4887-905. doi: 10.1093/hmg/ddu202. Epub 2014 May 2. Hum Mol Genet. 2014. PMID: 24794857 Free PMC article.
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
Ved R, Saha S, Westlund B, Perier C, Burnam L, Sluder A, Hoener M, Rodrigues CM, Alfonso A, Steer C, Liu L, Przedborski S, Wolozin B. Ved R, et al. Among authors: saha s. J Biol Chem. 2005 Dec 30;280(52):42655-42668. doi: 10.1074/jbc.M505910200. Epub 2005 Oct 19. J Biol Chem. 2005. PMID: 16239214 Free PMC article.
5,848 results