Kumar S - Search Results

1

Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediation.

Kumar S. Kumar S. Expert Opin Drug Metab Toxicol. 2010 Feb;6(2):115-31. doi: 10.1517/17425250903431040. Expert Opin Drug Metab Toxicol. 2010. PMID: 20064075 Free PMC article. Review.

2

Use of directed evolution of mammalian cytochromes P450 for investigating the molecular basis of enzyme function and generating novel biocatalysts.

Kumar S, Halpert JR. Kumar S, et al. Biochem Biophys Res Commun. 2005 Dec 9;338(1):456-64. doi: 10.1016/j.bbrc.2005.08.080. Epub 2005 Aug 22. Biochem Biophys Res Commun. 2005. PMID: 16126165 Review.

3

Alcohol consumption effect on antiretroviral therapy and HIV-1 pathogenesis: role of cytochrome P450 isozymes.

Kumar S, Jin M, Ande A, Sinha N, Silverstein PS, Kumar A. Kumar S, et al. Among authors: kumar a. Expert Opin Drug Metab Toxicol. 2012 Nov;8(11):1363-75. doi: 10.1517/17425255.2012.714366. Epub 2012 Aug 8. Expert Opin Drug Metab Toxicol. 2012. PMID: 22871069 Free PMC article. Review.

4

Tobacco smoking effect on HIV-1 pathogenesis: role of cytochrome P450 isozymes.

Ande A, McArthur C, Kumar A, Kumar S. Ande A, et al. Among authors: kumar s, kumar a. Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1453-64. doi: 10.1517/17425255.2013.816285. Epub 2013 Jul 4. Expert Opin Drug Metab Toxicol. 2013. PMID: 23822755 Free PMC article. Review.

5

Analysis of Cytochrome P450 Conserved Sequence Motifs between Helices E and H: Prediction of Critical Motifs and Residues in Enzyme Functions.

Oezguen N, Kumar S. Oezguen N, et al. Among authors: kumar s. J Drug Metab Toxicol. 2011 Aug 30;2:1000110. doi: 10.4172/2157-7609.1000110. J Drug Metab Toxicol. 2011. PMID: 25426333 Free PMC article.

6

Pharmacokinetics and pharmacodynamics of cytochrome P450 inhibitors for HIV treatment.

Gong Y, Haque S, Chowdhury P, Cory TJ, Kodidela S, Yallapu MM, Norwood JM, Kumar S. Gong Y, et al. Among authors: kumar s. Expert Opin Drug Metab Toxicol. 2019 May;15(5):417-427. doi: 10.1080/17425255.2019.1604685. Epub 2019 Apr 20. Expert Opin Drug Metab Toxicol. 2019. PMID: 30951643 Free PMC article. Review.

7

Nanotechnology approaches for delivery of cytochrome P450 substrates in HIV treatment.

Gong Y, Chowdhury P, Nagesh PKB, Cory TJ, Dezfuli C, Kodidela S, Singh A, Yallapu MM, Kumar S. Gong Y, et al. Among authors: kumar s. Expert Opin Drug Deliv. 2019 Aug;16(8):869-882. doi: 10.1080/17425247.2019.1646725. Epub 2019 Jul 24. Expert Opin Drug Deliv. 2019. PMID: 31328582 Free PMC article. Review.

8

Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity.

Kumar S, Davydov DR, Halpert JR. Kumar S, et al. Drug Metab Dispos. 2005 Aug;33(8):1131-6. doi: 10.1124/dmd.105.004606. Epub 2005 May 3. Drug Metab Dispos. 2005. PMID: 15870379

9

Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis.

Kumar S, Liu H, Halpert JR. Kumar S, et al. Drug Metab Dispos. 2006 Dec;34(12):1958-65. doi: 10.1124/dmd.106.012054. Epub 2006 Sep 20. Drug Metab Dispos. 2006. PMID: 16987939

10

Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide.

Kumar S, Sun L, Liu H, Muralidhara BK, Halpert JR. Kumar S, et al. Protein Eng Des Sel. 2006 Dec;19(12):547-54. doi: 10.1093/protein/gzl042. Epub 2006 Oct 18. Protein Eng Des Sel. 2006. PMID: 17050590

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