Smith M - Search Results

1

Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists.

Qiang L, Sasikumar TK, Burnett DA, Su J, Tang H, Ye Y, Mazzola RD Jr, Zhu Z, McKittrick BA, Greenlee WJ, Fawzi A, Smith M, Zhang H, Lachowicz JE. Qiang L, et al. Among authors: smith m. Bioorg Med Chem Lett. 2010 Feb 1;20(3):836-40. doi: 10.1016/j.bmcl.2009.12.100. Epub 2010 Jan 4. Bioorg Med Chem Lett. 2010. PMID: 20061148

2

Identification of 2-aminooxazole amides as acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) inhibitors through scaffold hopping strategy.

Kim HM, Smith MD, Kim JH, Caplen MA, Chan TY, McKittrick BA, Cook JA, van Heek M, Lachowicz J. Kim HM, et al. Among authors: smith md. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6410-4. doi: 10.1016/j.bmcl.2013.09.048. Epub 2013 Sep 25. Bioorg Med Chem Lett. 2013. PMID: 24120540

3

Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.

Wu WL, Burnett DA, Spring R, Greenlee WJ, Smith M, Favreau L, Fawzi A, Zhang H, Lachowicz JE. Wu WL, et al. Among authors: smith m. J Med Chem. 2005 Feb 10;48(3):680-93. doi: 10.1021/jm030614p. J Med Chem. 2005. PMID: 15689153

4

Remote functionalization of SCH 39166: discovery of potent and selective benzazepine dopamine D1 receptor antagonists.

Sasikumar TK, Burnett DA, Greenlee WJ, Smith M, Fawzi A, Zhang H, Lachowicz JE. Sasikumar TK, et al. Among authors: smith m. Bioorg Med Chem Lett. 2010 Feb 1;20(3):832-5. doi: 10.1016/j.bmcl.2009.12.094. Epub 2010 Jan 4. Bioorg Med Chem Lett. 2010. PMID: 20064718

5

A new sterol sulfate, Sch 572423, from a marine sponge, Topsentia sp.

Yang SW, Buivich A, Chan TM, Smith M, Lachowicz J, Pomponi SA, Wright AE, Mierzwa R, Patel M, Gullo V, Chu M. Yang SW, et al. Among authors: smith m. Bioorg Med Chem Lett. 2003 May 19;13(10):1791-4. doi: 10.1016/s0960-894x(03)00260-9. Bioorg Med Chem Lett. 2003. PMID: 12729666

6

Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.

Ting PC, Lee JF, Zorn N, Kim HM, Aslanian RG, Lin M, Smith M, Walker SS, Cook J, Van Heek M, Lachowicz J. Ting PC, et al. Among authors: smith m. Bioorg Med Chem Lett. 2013 Feb 15;23(4):985-8. doi: 10.1016/j.bmcl.2012.12.040. Epub 2012 Dec 21. Bioorg Med Chem Lett. 2013. PMID: 23317570

7

Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.

Zhou G, Ting PC, Wishart G, Zorn N, Aslanian RG, Lin M, Smith M, Walker SS, Cook J, Van Heek M, Lachowicz J. Zhou G, et al. Among authors: smith m. Bioorg Med Chem Lett. 2014 Apr 1;24(7):1790-4. doi: 10.1016/j.bmcl.2014.02.028. Epub 2014 Feb 19. Bioorg Med Chem Lett. 2014. PMID: 24618302

8

Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors.

Zhou G, Zorn N, Ting P, Aslanian R, Lin M, Cook J, Lachowicz J, Lin A, Smith M, Hwa J, van Heek M, Walker S. Zhou G, et al. Among authors: smith m. ACS Med Chem Lett. 2014 Mar 1;5(5):544-9. doi: 10.1021/ml400527n. eCollection 2014 May 8. ACS Med Chem Lett. 2014. PMID: 24900877 Free PMC article.

9

Discovery of [¹¹C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases.

Tong L, Li W, Lo MM, Gao X, Wai JM, Rudd M, Tellers D, Joshi A, Zeng Z, Miller P, Salinas C, Riffel K, Haley H, Purcell M, Holahan M, Gantert L, Schubert JW, Jones K, Mulhearn J, Egbertson M, Meng Z, Hanney B, Gomez R, Harrison ST, McQuade P, Bueters T, Uslaner J, Morrow J, Thomson F, Kong J, Liao J, Selyutin O, Bao J, Hastings NB, Agrawal S, Magliaro BC, Monsma FJ Jr, Smith MD, Risso S, Hesk D, Hostetler E, Mazzola R. Tong L, et al. Among authors: smith md. J Med Chem. 2020 Mar 12;63(5):2411-2425. doi: 10.1021/acs.jmedchem.9b01406. Epub 2020 Mar 3. J Med Chem. 2020. PMID: 32101422 Free article.

10

Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs.

Foster CJ, Prosser DM, Agans JM, Zhai Y, Smith MD, Lachowicz JE, Zhang FL, Gustafson E, Monsma FJ Jr, Wiekowski MT, Abbondanzo SJ, Cook DN, Bayne ML, Lira SA, Chintala MS. Foster CJ, et al. Among authors: smith md. J Clin Invest. 2001 Jun;107(12):1591-8. doi: 10.1172/JCI12242. J Clin Invest. 2001. PMID: 11413167 Free PMC article.

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