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Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses.
Villablanca EJ, Raccosta L, Zhou D, Fontana R, Maggioni D, Negro A, Sanvito F, Ponzoni M, Valentinis B, Bregni M, Prinetti A, Steffensen KR, Sonnino S, Gustafsson JA, Doglioni C, Bordignon C, Traversari C, Russo V. Villablanca EJ, et al. Among authors: fontana r. Nat Med. 2010 Jan;16(1):98-105. doi: 10.1038/nm.2074. Epub 2009 Dec 27. Nat Med. 2010. PMID: 20037595
Peripheral blood lymphocytes genetically modified to express the self/tumor antigen MAGE-A3 induce antitumor immune responses in cancer patients.
Fontana R, Bregni M, Cipponi A, Raccosta L, Rainelli C, Maggioni D, Lunghi F, Ciceri F, Mukenge S, Doglioni C, Colau D, Coulie PG, Bordignon C, Traversari C, Russo V. Fontana R, et al. Blood. 2009 Feb 19;113(8):1651-60. doi: 10.1182/blood-2008-07-168666. Epub 2008 Dec 12. Blood. 2009. PMID: 19074732 Free article. Clinical Trial.
The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils.
Raccosta L, Fontana R, Maggioni D, Lanterna C, Villablanca EJ, Paniccia A, Musumeci A, Chiricozzi E, Trincavelli ML, Daniele S, Martini C, Gustafsson JA, Doglioni C, Feo SG, Leiva A, Ciampa MG, Mauri L, Sensi C, Prinetti A, Eberini I, Mora JR, Bordignon C, Steffensen KR, Sonnino S, Sozzani S, Traversari C, Russo V. Raccosta L, et al. Among authors: fontana r. J Exp Med. 2013 Aug 26;210(9):1711-28. doi: 10.1084/jem.20130440. Epub 2013 Jul 29. J Exp Med. 2013. PMID: 23897983 Free PMC article.
The administration of drugs inhibiting cholesterol/oxysterol synthesis is safe and increases the efficacy of immunotherapeutic regimens in tumor-bearing mice.
Lanterna C, Musumeci A, Raccosta L, Corna G, Moresco M, Maggioni D, Fontana R, Doglioni C, Bordignon C, Traversari C, Russo V. Lanterna C, et al. Among authors: fontana r. Cancer Immunol Immunother. 2016 Nov;65(11):1303-1315. doi: 10.1007/s00262-016-1884-8. Epub 2016 Aug 12. Cancer Immunol Immunother. 2016. PMID: 27520505 Free PMC article.
Nuclear receptor ligands induce TREM-1 expression on dendritic cells: analysis of their role in tumors.
Fontana R, Raccosta L, Rovati L, Steffensen KR, Paniccia A, Jakobsson T, Melloni G, Bandiera A, Mangili G, Bergamini A, Maggioni D, Doglioni C, Crocchiolo R, Cella M, Mattioli M, Battaglia C, Colonna M, Russo V. Fontana R, et al. Oncoimmunology. 2018 Dec 13;8(3):1554967. doi: 10.1080/2162402X.2018.1554967. eCollection 2019. Oncoimmunology. 2018. PMID: 30723587 Free PMC article.
929 results