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Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis.
Li Z, Huang H, Boland P, Dominguez MG, Burfeind P, Lai KM, Lin HC, Gale NW, Daly C, Auerbach W, Valenzuela D, Yancopoulos GD, Thurston G. Li Z, et al. Among authors: auerbach w. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22399-404. doi: 10.1073/pnas.0911189106. Epub 2009 Dec 15. Proc Natl Acad Sci U S A. 2009. PMID: 20018779 Free PMC article.
Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes.
Macdonald LE, Karow M, Stevens S, Auerbach W, Poueymirou WT, Yasenchak J, Frendewey D, Valenzuela DM, Giallourakis CC, Alt FW, Yancopoulos GD, Murphy AJ. Macdonald LE, et al. Among authors: auerbach w. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5147-52. doi: 10.1073/pnas.1323896111. Epub 2014 Mar 25. Proc Natl Acad Sci U S A. 2014. PMID: 24706858 Free PMC article.
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis.
Valenzuela DM, Murphy AJ, Frendewey D, Gale NW, Economides AN, Auerbach W, Poueymirou WT, Adams NC, Rojas J, Yasenchak J, Chernomorsky R, Boucher M, Elsasser AL, Esau L, Zheng J, Griffiths JA, Wang X, Su H, Xue Y, Dominguez MG, Noguera I, Torres R, Macdonald LE, Stewart AF, DeChiara TM, Yancopoulos GD. Valenzuela DM, et al. Among authors: auerbach w. Nat Biotechnol. 2003 Jun;21(6):652-9. doi: 10.1038/nbt822. Epub 2003 May 5. Nat Biotechnol. 2003. PMID: 12730667
Conditionals by inversion provide a universal method for the generation of conditional alleles.
Economides AN, Frendewey D, Yang P, Dominguez MG, Dore AT, Lobov IB, Persaud T, Rojas J, McClain J, Lengyel P, Droguett G, Chernomorsky R, Stevens S, Auerbach W, Dechiara TM, Pouyemirou W, Cruz JM Jr, Feeley K, Mellis IA, Yasenchack J, Hatsell SJ, Xie L, Latres E, Huang L, Zhang Y, Pefanis E, Skokos D, Deckelbaum RA, Croll SD, Davis S, Valenzuela DM, Gale NW, Murphy AJ, Yancopoulos GD. Economides AN, et al. Among authors: auerbach w. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3179-88. doi: 10.1073/pnas.1217812110. Epub 2013 Aug 5. Proc Natl Acad Sci U S A. 2013. PMID: 23918385 Free PMC article.
Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung.
Willinger T, Rongvaux A, Takizawa H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Auerbach W, Eynon EE, Stevens S, Manz MG, Flavell RA. Willinger T, et al. Among authors: auerbach w. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2390-5. doi: 10.1073/pnas.1019682108. Epub 2011 Jan 24. Proc Natl Acad Sci U S A. 2011. PMID: 21262803 Free PMC article.
Generation of fertile and fecund F0 XY female mice from XY ES cells.
Kuno J, Poueymirou WT, Gong G, Siao CJ, Clarke G, Esau L, Kojak N, Posca J, Atanasio A, Strein J, Yancopoulos GD, Lai KM, DeChiara TM, Frendewey D, Auerbach W, Valenzuela DM. Kuno J, et al. Among authors: auerbach w. Transgenic Res. 2015 Feb;24(1):19-29. doi: 10.1007/s11248-014-9815-y. Epub 2014 Aug 3. Transgenic Res. 2015. PMID: 25087174
Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties.
Macdonald LE, Meagher KA, Franklin MC, Levenkova N, Hansen J, Badithe AT, Zhong M, Krueger P, Rafique A, Tu N, Shevchuk J, Wadhwa S, Ehrlich G, Bautista J, Grant C, Esau L, Poueymirou WT, Auerbach W, Morton L, Babb R, Chen G, Huang T, MacDonald D, Graham K, Gurer C, Voronina VA, McWhirter JR, Guo C, Yancopoulos GD, Murphy AJ. Macdonald LE, et al. Among authors: auerbach w. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):292-299. doi: 10.1073/pnas.1901734117. Epub 2019 Dec 26. Proc Natl Acad Sci U S A. 2020. PMID: 31879340 Free PMC article.
44 results