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AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.
Kobayashi M, Aida M, Nagaoka H, Begum NA, Kitawaki Y, Nakata M, Stanlie A, Doi T, Kato L, Okazaki IM, Shinkura R, Muramatsu M, Kinoshita K, Honjo T. Kobayashi M, et al. Among authors: kinoshita k. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22375-80. doi: 10.1073/pnas.0911879106. Epub 2009 Dec 11. Proc Natl Acad Sci U S A. 2009. PMID: 20018730 Free PMC article.
Constitutive expression of AID leads to tumorigenesis.
Okazaki IM, Hiai H, Kakazu N, Yamada S, Muramatsu M, Kinoshita K, Honjo T. Okazaki IM, et al. Among authors: kinoshita k. J Exp Med. 2003 May 5;197(9):1173-81. doi: 10.1084/jem.20030275. J Exp Med. 2003. PMID: 12732658 Free PMC article.
AID mutant analyses indicate requirement for class-switch-specific cofactors.
Ta VT, Nagaoka H, Catalan N, Durandy A, Fischer A, Imai K, Nonoyama S, Tashiro J, Ikegawa M, Ito S, Kinoshita K, Muramatsu M, Honjo T. Ta VT, et al. Among authors: kinoshita k. Nat Immunol. 2003 Sep;4(9):843-8. doi: 10.1038/ni964. Epub 2003 Aug 10. Nat Immunol. 2003. PMID: 12910268
2,507 results