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rs2476601 T allele (R620W) defines high-risk PTPN22 type I diabetes-associated haplotypes with preliminary evidence for an additional protective haplotype.
Steck AK, Baschal EE, Jasinski JM, Boehm BO, Bottini N, Concannon P, Julier C, Morahan G, Noble JA, Polychronakos C, She JX, Eisenbarth GS; Type I Diabetes Genetics Consortium. Steck AK, et al. Among authors: noble ja. Genes Immun. 2009 Dec;10 Suppl 1(Suppl 1):S21-6. doi: 10.1038/gene.2009.87. Genes Immun. 2009. PMID: 19956096 Free PMC article.
Sequence analysis of the diabetes-protective human leukocyte antigen-DQB1*0602 allele in unaffected, islet cell antibody-positive first degree relatives and in rare patients with type 1 diabetes.
Pugliese A, Kawasaki E, Zeller M, Yu L, Babu S, Solimena M, Moraes CT, Pietropaolo M, Friday RP, Trucco M, Ricordi C, Allen M, Noble JA, Erlich HA, Eisenbarth GS. Pugliese A, et al. Among authors: noble ja. J Clin Endocrinol Metab. 1999 May;84(5):1722-8. doi: 10.1210/jcem.84.5.5684. J Clin Endocrinol Metab. 1999. PMID: 10323407
391 results