Opferman JT - Search Results

1

MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts.

Brunelle JK, Ryan J, Yecies D, Opferman JT, Letai A. Brunelle JK, et al. Among authors: opferman jt. J Cell Biol. 2009 Nov 2;187(3):429-42. doi: 10.1083/jcb.200904049. Epub 2009 Oct 26. J Cell Biol. 2009. PMID: 19948485 Free PMC article.

2

Apoptosis in the development and maintenance of the immune system.

Opferman JT, Korsmeyer SJ. Opferman JT, et al. Nat Immunol. 2003 May;4(5):410-5. doi: 10.1038/ni0503-410. Nat Immunol. 2003. PMID: 12719730 Review.

3

Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members.

Oakes SA, Opferman JT, Pozzan T, Korsmeyer SJ, Scorrano L. Oakes SA, et al. Among authors: opferman jt. Biochem Pharmacol. 2003 Oct 15;66(8):1335-40. doi: 10.1016/s0006-2952(03)00482-9. Biochem Pharmacol. 2003. PMID: 14555206 Review.

4

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ. Opferman JT, et al. Nature. 2003 Dec 11;426(6967):671-6. doi: 10.1038/nature02067. Nature. 2003. PMID: 14668867 Free article.

5

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

Opferman JT, Iwasaki H, Ong CC, Suh H, Mizuno S, Akashi K, Korsmeyer SJ. Opferman JT, et al. Science. 2005 Feb 18;307(5712):1101-4. doi: 10.1126/science.1106114. Science. 2005. PMID: 15718471

6

Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance.

Wei G, Twomey D, Lamb J, Schlis K, Agarwal J, Stam RW, Opferman JT, Sallan SE, den Boer ML, Pieters R, Golub TR, Armstrong SA. Wei G, et al. Among authors: opferman jt. Cancer Cell. 2006 Oct;10(4):331-42. doi: 10.1016/j.ccr.2006.09.006. Epub 2006 Sep 28. Cancer Cell. 2006. PMID: 17010674 Free article.

7

A pivotal role for Mcl-1 in Bortezomib-induced apoptosis.

Podar K, Gouill SL, Zhang J, Opferman JT, Zorn E, Tai YT, Hideshima T, Amiot M, Chauhan D, Harousseau JL, Anderson KC. Podar K, et al. Among authors: opferman jt. Oncogene. 2008 Jan 31;27(6):721-31. doi: 10.1038/sj.onc.1210679. Epub 2007 Jul 23. Oncogene. 2008. PMID: 17653083

8

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.

Xiang Z, Luo H, Payton JE, Cain J, Ley TJ, Opferman JT, Tomasson MH. Xiang Z, et al. Among authors: opferman jt. J Clin Invest. 2010 Jun;120(6):2109-18. doi: 10.1172/JCI39964. Epub 2010 May 17. J Clin Invest. 2010. PMID: 20484815 Free PMC article.

9

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.

Perciavalle RM, Stewart DP, Koss B, Lynch J, Milasta S, Bathina M, Temirov J, Cleland MM, Pelletier S, Schuetz JD, Youle RJ, Green DR, Opferman JT. Perciavalle RM, et al. Among authors: opferman jt. Nat Cell Biol. 2012 Apr 29;14(6):575-83. doi: 10.1038/ncb2488. Nat Cell Biol. 2012. PMID: 22544066 Free PMC article.

10

A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival.

Cohen NA, Stewart ML, Gavathiotis E, Tepper JL, Bruekner SR, Koss B, Opferman JT, Walensky LD. Cohen NA, et al. Among authors: opferman jt. Chem Biol. 2012 Sep 21;19(9):1175-86. doi: 10.1016/j.chembiol.2012.07.018. Chem Biol. 2012. PMID: 22999885 Free PMC article.

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