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The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Koeberle A, Rossi A, Zettl H, Pergola C, Dehm F, Bauer J, Greiner C, Reckel S, Hoernig C, Northoff H, Bernhard F, Dötsch V, Sautebin L, Schubert-Zsilavecz M, Werz O. Koeberle A, et al. Among authors: werz o. J Pharmacol Exp Ther. 2010 Mar;332(3):840-8. doi: 10.1124/jpet.109.160663. Epub 2009 Nov 24. J Pharmacol Exp Ther. 2010. PMID: 19934399
Therapeutic options for 5-lipoxygenase inhibitors.
Werz O, Steinhilber D. Werz O, et al. Pharmacol Ther. 2006 Dec;112(3):701-18. doi: 10.1016/j.pharmthera.2006.05.009. Epub 2006 Jul 11. Pharmacol Ther. 2006. PMID: 16837050 Review.
423 results