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Page 1
Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.
Bunnelle WH, Daanen JF, Ryther KB, Schrimpf MR, Dart MJ, Gelain A, Meyer MD, Frost JM, Anderson DJ, Buckley M, Curzon P, Cao YJ, Puttfarcken P, Searle X, Ji J, Putman CB, Surowy C, Toma L, Barlocco D. Bunnelle WH, et al. Among authors: meyer md. J Med Chem. 2007 Jul 26;50(15):3627-44. doi: 10.1021/jm070018l. Epub 2007 Jun 22. J Med Chem. 2007. PMID: 17585748
Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging.
Yao BB, Hsieh G, Daza AV, Fan Y, Grayson GK, Garrison TR, El Kouhen O, Hooker BA, Pai M, Wensink EJ, Salyers AK, Chandran P, Zhu CZ, Zhong C, Ryther K, Gallagher ME, Chin CL, Tovcimak AE, Hradil VP, Fox GB, Dart MJ, Honore P, Meyer MD. Yao BB, et al. Among authors: meyer md. J Pharmacol Exp Ther. 2009 Jan;328(1):141-51. doi: 10.1124/jpet.108.145011. Epub 2008 Oct 17. J Pharmacol Exp Ther. 2009. PMID: 18931146
Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.
Bunnelle WH, Tietje KR, Frost JM, Peters D, Ji J, Li T, Scanio MJ, Shi L, Anderson DJ, Dyhring T, Grønlien JH, Ween H, Thorin-Hagene K, Meyer MD. Bunnelle WH, et al. Among authors: meyer md. J Med Chem. 2009 Jul 23;52(14):4126-41. doi: 10.1021/jm900249k. J Med Chem. 2009. PMID: 19552432
Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB₂ receptor agonists for pain management.
Nelson DW, Frost JM, Tietje KR, Florjancic AS, Ryther K, Carroll WA, Dart MJ, Daza AV, Hooker BA, Grayson GK, Fan Y, Garrison TR, El-Kouhen OF, Yao B, Pai M, Chandran P, Zhu C, Hsieh GC, Meyer MD. Nelson DW, et al. Among authors: meyer md. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2604-8. doi: 10.1016/j.bmcl.2012.01.121. Epub 2012 Feb 4. Bioorg Med Chem Lett. 2012. PMID: 22370265
Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI.
Chin CL, Tovcimak AE, Hradil VP, Seifert TR, Hollingsworth PR, Chandran P, Zhu CZ, Gauvin D, Pai M, Wetter J, Hsieh GC, Honore P, Frost JM, Dart MJ, Meyer MD, Yao BB, Cox BF, Fox GB. Chin CL, et al. Among authors: meyer md. Br J Pharmacol. 2008 Jan;153(2):367-79. doi: 10.1038/sj.bjp.0707506. Epub 2007 Oct 29. Br J Pharmacol. 2008. PMID: 17965748 Free PMC article.
125 results