Hyman BT - Search Results

1

Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron.

Hillmer AS, Putcha P, Levin J, Högen T, Hyman BT, Kretzschmar H, McLean PJ, Giese A. Hillmer AS, et al. Among authors: hyman bt. Biochem Biophys Res Commun. 2010 Jan 1;391(1):461-6. doi: 10.1016/j.bbrc.2009.11.080. Epub 2009 Nov 13. Biochem Biophys Res Commun. 2010. PMID: 19914207 Free PMC article.

2

Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro.

McLean PJ, Klucken J, Shin Y, Hyman BT. McLean PJ, et al. Among authors: hyman bt. Biochem Biophys Res Commun. 2004 Aug 27;321(3):665-9. doi: 10.1016/j.bbrc.2004.07.021. Biochem Biophys Res Commun. 2004. PMID: 15358157

3

A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity.

Klucken J, Shin Y, Hyman BT, McLean PJ. Klucken J, et al. Among authors: hyman bt. Biochem Biophys Res Commun. 2004 Dec 3;325(1):367-73. doi: 10.1016/j.bbrc.2004.10.037. Biochem Biophys Res Commun. 2004. PMID: 15522241

4

Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation.

Outeiro TF, Klucken J, Strathearn KE, Liu F, Nguyen P, Rochet JC, Hyman BT, McLean PJ. Outeiro TF, et al. Among authors: hyman bt. Biochem Biophys Res Commun. 2006 Dec 22;351(3):631-8. doi: 10.1016/j.bbrc.2006.10.085. Epub 2006 Oct 26. Biochem Biophys Res Commun. 2006. PMID: 17081499 Free PMC article.

5

Formation of toxic oligomeric alpha-synuclein species in living cells.

Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ. Outeiro TF, et al. Among authors: hyman bt. PLoS One. 2008 Apr 2;3(4):e1867. doi: 10.1371/journal.pone.0001867. PLoS One. 2008. PMID: 18382657 Free PMC article.

6

CHIP targets toxic alpha-Synuclein oligomers for degradation.

Tetzlaff JE, Putcha P, Outeiro TF, Ivanov A, Berezovska O, Hyman BT, McLean PJ. Tetzlaff JE, et al. Among authors: hyman bt. J Biol Chem. 2008 Jun 27;283(26):17962-8. doi: 10.1074/jbc.M802283200. Epub 2008 Apr 24. J Biol Chem. 2008. PMID: 18436529 Free PMC article.

7

Dopamine-induced conformational changes in alpha-synuclein.

Outeiro TF, Klucken J, Bercury K, Tetzlaff J, Putcha P, Oliveira LM, Quintas A, McLean PJ, Hyman BT. Outeiro TF, et al. Among authors: hyman bt. PLoS One. 2009 Sep 4;4(9):e6906. doi: 10.1371/journal.pone.0006906. PLoS One. 2009. PMID: 19730729 Free PMC article.

8

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity.

Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ. Danzer KM, et al. Among authors: hyman bt. FASEB J. 2011 Jan;25(1):326-36. doi: 10.1096/fj.10-164624. Epub 2010 Sep 27. FASEB J. 2011. PMID: 20876215 Free PMC article.

9

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity.

Klucken J, Shin Y, Masliah E, Hyman BT, McLean PJ. Klucken J, et al. Among authors: hyman bt. J Biol Chem. 2004 Jun 11;279(24):25497-502. doi: 10.1074/jbc.M400255200. Epub 2004 Mar 25. J Biol Chem. 2004. PMID: 15044495 Free article.

10

Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity.

Putcha P, Danzer KM, Kranich LR, Scott A, Silinski M, Mabbett S, Hicks CD, Veal JM, Steed PM, Hyman BT, McLean PJ. Putcha P, et al. Among authors: hyman bt. J Pharmacol Exp Ther. 2010 Mar;332(3):849-57. doi: 10.1124/jpet.109.158436. Epub 2009 Nov 24. J Pharmacol Exp Ther. 2010. PMID: 19934398 Free PMC article.

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