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Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload.
Kaludercic N, Takimoto E, Nagayama T, Feng N, Lai EW, Bedja D, Chen K, Gabrielson KL, Blakely RD, Shih JC, Pacak K, Kass DA, Di Lisa F, Paolocci N. Kaludercic N, et al. Among authors: nagayama t. Circ Res. 2010 Jan 8;106(1):193-202. doi: 10.1161/CIRCRESAHA.109.198366. Epub 2009 Nov 12. Circ Res. 2010. PMID: 19910579 Free PMC article.
Pathological cardiac hypertrophy alters intracellular targeting of phosphodiesterase type 5 from nitric oxide synthase-3 to natriuretic peptide signaling.
Zhang M, Takimoto E, Lee DI, Santos CX, Nakamura T, Hsu S, Jiang A, Nagayama T, Bedja D, Yuan Y, Eaton P, Shah AM, Kass DA. Zhang M, et al. Among authors: nagayama t. Circulation. 2012 Aug 21;126(8):942-51. doi: 10.1161/CIRCULATIONAHA.112.090977. Epub 2012 Jul 24. Circulation. 2012. PMID: 22829024 Free PMC article.
Phosphodiesterase regulation of nitric oxide signaling.
Kass DA, Takimoto E, Nagayama T, Champion HC. Kass DA, et al. Among authors: nagayama t. Cardiovasc Res. 2007 Jul 15;75(2):303-14. doi: 10.1016/j.cardiores.2007.02.031. Epub 2007 Mar 2. Cardiovasc Res. 2007. PMID: 17467673 Review.
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.
Takimoto E, Koitabashi N, Hsu S, Ketner EA, Zhang M, Nagayama T, Bedja D, Gabrielson KL, Blanton R, Siderovski DP, Mendelsohn ME, Kass DA. Takimoto E, et al. Among authors: nagayama t. J Clin Invest. 2009 Feb;119(2):408-20. doi: 10.1172/JCI35620. Epub 2009 Jan 5. J Clin Invest. 2009. PMID: 19127022 Free PMC article.
511 results