Blaskovich MA - Search Results

1

Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies.

Hong DS, Sebti SM, Newman RA, Blaskovich MA, Ye L, Gagel RF, Moulder S, Wheler JJ, Naing A, Tannir NM, Ng CS, Sherman SI, El Naggar AK, Khan R, Trent J, Wright JJ, Kurzrock R. Hong DS, et al. Among authors: blaskovich ma. Clin Cancer Res. 2009 Nov 15;15(22):7061-8. doi: 10.1158/1078-0432.CCR-09-1241. Epub 2009 Nov 10. Clin Cancer Res. 2009. PMID: 19903778 Free PMC article. Clinical Trial.

2

A phase I clinical-pharmacodynamic study of the farnesyltransferase inhibitor tipifarnib in combination with the proteasome inhibitor bortezomib in advanced acute leukemias.

Lancet JE, Duong VH, Winton EF, Stuart RK, Burton M, Zhang S, Cubitt C, Blaskovich MA, Wright JJ, Sebti S, Sullivan DM. Lancet JE, et al. Among authors: blaskovich ma. Clin Cancer Res. 2011 Mar 1;17(5):1140-6. doi: 10.1158/1078-0432.CCR-10-1878. Epub 2011 Jan 13. Clin Cancer Res. 2011. PMID: 21233404 Free PMC article. Clinical Trial.

3

Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.

Sun J, Blaskovich MA, Knowles D, Qian Y, Ohkanda J, Bailey RD, Hamilton AD, Sebti SM. Sun J, et al. Among authors: blaskovich ma. Cancer Res. 1999 Oct 1;59(19):4919-26. Cancer Res. 1999. PMID: 10519405

4

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM. Blaskovich MA, et al. Cancer Res. 2003 Mar 15;63(6):1270-9. Cancer Res. 2003. PMID: 12649187

5

Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104).

Gajewski TF, Salama AK, Niedzwiecki D, Johnson J, Linette G, Bucher C, Blaskovich MA, Sebti SM, Haluska F; Cancer and Leukemia Group B. Gajewski TF, et al. Among authors: blaskovich ma. J Transl Med. 2012 Dec 10;10:246. doi: 10.1186/1479-5876-10-246. J Transl Med. 2012. PMID: 23228035 Free PMC article. Clinical Trial.

6

The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents.

Ohkanda J, Blaskovich MA, Sebti SM, Hamilton AD. Ohkanda J, et al. Among authors: blaskovich ma. Prog Cell Cycle Res. 2003;5:211-7. Prog Cell Cycle Res. 2003. PMID: 14593715 Review.

7

Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor.

Sun J, Blaskovich MA, Jain RK, Delarue F, Paris D, Brem S, Wotoczek-Obadia M, Lin Q, Coppola D, Choi K, Mullan M, Hamilton AD, Sebti SM. Sun J, et al. Among authors: blaskovich ma. Cancer Res. 2004 May 15;64(10):3586-92. doi: 10.1158/0008-5472.CAN-03-2673. Cancer Res. 2004. PMID: 15150116

8

Inhibitors of protein farnesyltransferase as novel anticancer agents.

Ohkanda J, Knowles DB, Blaskovich MA, Sebti SM, Hamilton AD. Ohkanda J, et al. Among authors: blaskovich ma. Curr Top Med Chem. 2002 Mar;2(3):303-23. doi: 10.2174/1568026023394281. Curr Top Med Chem. 2002. PMID: 11944822 Review.

9

Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours.

Zhang X, Blaskovich MA, Forinash KD, Sebti SM. Zhang X, et al. Among authors: blaskovich ma. Br J Cancer. 2014 Aug 26;111(5):894-902. doi: 10.1038/bjc.2014.349. Epub 2014 Jul 1. Br J Cancer. 2014. PMID: 24983364 Free PMC article.

10

Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling.

Epling-Burnette PK, Sokol L, Chen X, Bai F, Zhou J, Blaskovich MA, Zou J, Painter JS, Edwards TD, Moscinski L, Yoder JA, Djeu JY, Sebti S, Loughran TP Jr, Wei S. Epling-Burnette PK, et al. Among authors: blaskovich ma. Blood. 2008 Dec 1;112(12):4694-8. doi: 10.1182/blood-2008-02-136382. Epub 2008 Sep 12. Blood. 2008. PMID: 18791165 Free PMC article.

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