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Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells.
Carter BZ, Gronda M, Wang Z, Welsh K, Pinilla C, Andreeff M, Schober WD, Nefzi A, Pond GR, Mawji IA, Houghten RA, Ostresh J, Brandwein J, Minden MD, Schuh AC, Wells RA, Messner H, Chun K, Reed JC, Schimmer AD. Carter BZ, et al. Among authors: pinilla c. Blood. 2005 May 15;105(10):4043-50. doi: 10.1182/blood-2004-08-3168. Epub 2005 Feb 1. Blood. 2005. PMID: 15687241 Free PMC article.
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.
Schimmer AD, Welsh K, Pinilla C, Wang Z, Krajewska M, Bonneau MJ, Pedersen IM, Kitada S, Scott FL, Bailly-Maitre B, Glinsky G, Scudiero D, Sausville E, Salvesen G, Nefzi A, Ostresh JM, Houghten RA, Reed JC. Schimmer AD, et al. Among authors: pinilla c. Cancer Cell. 2004 Jan;5(1):25-35. doi: 10.1016/s1535-6108(03)00332-5. Cancer Cell. 2004. PMID: 14749124 Free article.
Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors.
Wang Z, Cuddy M, Samuel T, Welsh K, Schimmer A, Hanaii F, Houghten R, Pinilla C, Reed JC. Wang Z, et al. Among authors: pinilla c. J Biol Chem. 2004 Nov 12;279(46):48168-76. doi: 10.1074/jbc.M405022200. Epub 2004 Aug 27. J Biol Chem. 2004. PMID: 15337764 Free article.
A phenylurea series of chemical inhibitors of XIAP was recently generated by our laboratories (Schimmer, A. D., Welsh, K., Pinilla, C., Bonneau, M., Wang, Z., Pedersen, I. M., Scott, F. L., Glinsky, G. V., Scudiero, D. A., Sausville, E., Salvesen, G., Nefzi, A., Ost …
A phenylurea series of chemical inhibitors of XIAP was recently generated by our laboratories (Schimmer, A. D., Welsh, K., Pinilla, …
193 results