Gilissen RA - Search Results

1

Cardio-vascular safety beyond hERG: in silico modelling of a guinea pig right atrium assay.

Fenu LA, Teisman A, De Buck SS, Sinha VK, Gilissen RA, Nijsen MJ, Mackie CE, Sanderson WE. Fenu LA, et al. Among authors: gilissen ra. J Comput Aided Mol Des. 2009 Dec;23(12):883-95. doi: 10.1007/s10822-009-9306-z. Epub 2009 Nov 5. J Comput Aided Mol Des. 2009. PMID: 19890608

2

The prediction of drug metabolism, tissue distribution, and bioavailability of 50 structurally diverse compounds in rat using mechanism-based absorption, distribution, and metabolism prediction tools.

De Buck SS, Sinha VK, Fenu LA, Gilissen RA, Mackie CE, Nijsen MJ. De Buck SS, et al. Among authors: gilissen ra. Drug Metab Dispos. 2007 Apr;35(4):649-59. doi: 10.1124/dmd.106.014027. Epub 2007 Jan 31. Drug Metab Dispos. 2007. PMID: 17267621

3

Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs.

De Buck SS, Sinha VK, Fenu LA, Nijsen MJ, Mackie CE, Gilissen RA. De Buck SS, et al. Among authors: gilissen ra. Drug Metab Dispos. 2007 Oct;35(10):1766-80. doi: 10.1124/dmd.107.015644. Epub 2007 Jul 9. Drug Metab Dispos. 2007. PMID: 17620347

4

Predicting oral clearance in humans: how close can we get with allometry?

Sinha VK, De Buck SS, Fenu LA, Smit JW, Nijsen M, Gilissen RA, Van Peer A, Lavrijsen K, Mackie CE. Sinha VK, et al. Among authors: gilissen ra. Clin Pharmacokinet. 2008;47(1):35-45. doi: 10.2165/00003088-200847010-00004. Clin Pharmacokinet. 2008. PMID: 18076217

5

Towards a better prediction of peak concentration, volume of distribution and half-life after oral drug administration in man, using allometry.

Sinha VK, Vaarties K, De Buck SS, Fenu LA, Nijsen M, Gilissen RA, Sanderson W, Van Uytsel K, Hoeben E, Van Peer A, Mackie CE, Smit JW. Sinha VK, et al. Among authors: gilissen ra. Clin Pharmacokinet. 2011 May;50(5):307-18. doi: 10.2165/11539250-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21456631

6

Prediction of human oral plasma concentration-time profiles using preclinical data: comparative evaluation of prediction approaches in early pharmaceutical discovery.

Van den Bergh A, Sinha V, Gilissen R, Straetemans R, Wuyts K, Morrison D, Bijnens L, Mackie C. Van den Bergh A, et al. Clin Pharmacokinet. 2011 Aug;50(8):505-17. doi: 10.2165/11587230-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21740074

7

Simultaneous measurement of metabolic stability and metabolite identification of 7-methoxymethylthiazolo[3,2-a]pyrimidin-5-one derivatives in human liver microsomes using liquid chromatography/ion-trap mass spectrometry.

Kantharaj E, Ehmer PB, Tuytelaars A, Van Vlaslaer A, Mackie C, Gilissen RA. Kantharaj E, et al. Among authors: gilissen ra. Rapid Commun Mass Spectrom. 2005;19(8):1069-74. doi: 10.1002/rcm.1891. Rapid Commun Mass Spectrom. 2005. PMID: 15776495

8

The use of liquid chromatography-atmospheric pressure chemical ionization mass spectrometry to explore the in vitro metabolism of cyanoalkyl piperidine derivatives.

Kantharaj E, Ehmer PB, De Wagter K, Tuytelaars A, Proost PE, Mackie C, Gilissen RA. Kantharaj E, et al. Among authors: gilissen ra. Biomed Chromatogr. 2005 Apr;19(3):245-9. doi: 10.1002/bmc.449. Biomed Chromatogr. 2005. PMID: 15627277

9

Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.

Angibaud P, Van Emelen K, Decrane L, van Brandt S, Ten Holte P, Pilatte I, Roux B, Poncelet V, Speybrouck D, Queguiner L, Gaurrand S, Mariën A, Floren W, Janssen L, Verdonck M, van Dun J, van Gompel J, Gilissen R, Mackie C, Du Jardin M, Peeters J, Noppe M, Van Hijfte L, Freyne E, Page M, Janicot M, Arts J. Angibaud P, et al. Bioorg Med Chem Lett. 2010 Jan 1;20(1):294-8. doi: 10.1016/j.bmcl.2009.10.118. Epub 2009 Oct 30. Bioorg Med Chem Lett. 2010. PMID: 19906529

10

Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients.

de Witte WE, Wong YC, Nederpelt I, Heitman LH, Danhof M, van der Graaf PH, Gilissen RA, de Lange EC. de Witte WE, et al. Among authors: gilissen ra. Expert Opin Drug Discov. 2016;11(1):45-63. doi: 10.1517/17460441.2016.1100163. Epub 2015 Oct 20. Expert Opin Drug Discov. 2016. PMID: 26484747 Review.

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