Perreault M - Search Results

1

The human UGT1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver.

Trottier J, El Husseini D, Perreault M, Pâquet S, Caron P, Bourassa S, Verreault M, Inaba TT, Poirier GG, Bélanger A, Guillemette C, Trauner M, Barbier O. Trottier J, et al. Among authors: perreault m. J Biol Chem. 2010 Jan 8;285(2):1113-21. doi: 10.1074/jbc.M109.073908. Epub 2009 Nov 4. J Biol Chem. 2010. PMID: 19889628 Free PMC article.

2

The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation.

Perreault M, Gauthier-Landry L, Trottier J, Verreault M, Caron P, Finel M, Barbier O. Perreault M, et al. Drug Metab Dispos. 2013 Sep;41(9):1616-20. doi: 10.1124/dmd.113.052613. Epub 2013 Jun 11. Drug Metab Dispos. 2013. PMID: 23756265 Free PMC article.

3

Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions.

Perreault M, Wunsch E, Białek A, Trottier J, Verreault M, Caron P, Poirier GG, Milkiewicz P, Barbier O. Perreault M, et al. Can J Gastroenterol Hepatol. 2018 Apr 11;2018:8096314. doi: 10.1155/2018/8096314. eCollection 2018. Can J Gastroenterol Hepatol. 2018. PMID: 29850459 Free PMC article.

4

Profiling serum bile acid glucuronides in humans: gender divergences, genetic determinants, and response to fenofibrate.

Trottier J, Perreault M, Rudkowska I, Levy C, Dallaire-Theroux A, Verreault M, Caron P, Staels B, Vohl MC, Straka RJ, Barbier O. Trottier J, et al. Among authors: perreault m. Clin Pharmacol Ther. 2013 Oct;94(4):533-43. doi: 10.1038/clpt.2013.122. Epub 2013 Jun 12. Clin Pharmacol Ther. 2013. PMID: 23756370 Free PMC article. Clinical Trial.

5

Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential.

Verreault M, Kaeding J, Caron P, Trottier J, Grosse L, Houssin E, Pâquet S, Perreault M, Barbier O. Verreault M, et al. Among authors: perreault m. Drug Metab Rev. 2010 Feb;42(1):110-22. doi: 10.3109/03602530903219220. Drug Metab Rev. 2010. PMID: 19831728 Review.

6

Role of glucuronidation for hepatic detoxification and urinary elimination of toxic bile acids during biliary obstruction.

Perreault M, Białek A, Trottier J, Verreault M, Caron P, Milkiewicz P, Barbier O. Perreault M, et al. PLoS One. 2013 Nov 14;8(11):e80994. doi: 10.1371/journal.pone.0080994. eCollection 2013. PLoS One. 2013. PMID: 24244729 Free PMC article.

7

Omega-3 Polyunsaturated Fatty Acid: A Pharmaco-Nutraceutical Approach to Improve the Responsiveness to Ursodeoxycholic Acid.

Thérien A, Cieślak A, Verreault M, Perreault M, Trottier J, Gobeil S, Vohl MC, Barbier O. Thérien A, et al. Among authors: perreault m. Nutrients. 2021 Jul 29;13(8):2617. doi: 10.3390/nu13082617. Nutrients. 2021. PMID: 34444777 Free PMC article.

8

A- and D-Ring Structural Modifications of an Androsterone Derivative Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3: Chemical Synthesis and Structure-Activity Relationships.

Cortés-Benítez F, Roy J, Perreault M, Maltais R, Poirier D. Cortés-Benítez F, et al. Among authors: perreault m. J Med Chem. 2019 Aug 8;62(15):7070-7088. doi: 10.1021/acs.jmedchem.9b00624. Epub 2019 Jul 19. J Med Chem. 2019. PMID: 31268309

9

Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility.

Maltais R, Perreault M, Roy J, Poirier D. Maltais R, et al. Among authors: perreault m. Eur J Med Chem. 2020 Feb 15;188:111990. doi: 10.1016/j.ejmech.2019.111990. Epub 2019 Dec 23. Eur J Med Chem. 2020. PMID: 31893547

10

Synthesis and biological evaluation of novel 1,4-benzodiazepin-3-one derivatives as potential antitumor agents against prostate cancer.

Vézina-Dawod S, Perreault M, Guay LD, Gerber N, Gobeil S, Biron E. Vézina-Dawod S, et al. Among authors: perreault m. Bioorg Med Chem. 2021 Sep 1;45:116314. doi: 10.1016/j.bmc.2021.116314. Epub 2021 Jul 21. Bioorg Med Chem. 2021. PMID: 34333393 Free article.

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