Fotovati A - Search Results

1

Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas.

Hu K, Lee C, Qiu D, Fotovati A, Davies A, Abu-Ali S, Wai D, Lawlor ER, Triche TJ, Pallen CJ, Dunn SE. Hu K, et al. Among authors: fotovati a. Mol Cancer Ther. 2009 Nov;8(11):3024-35. doi: 10.1158/1535-7163.MCT-09-0365. Epub 2009 Nov 3. Mol Cancer Ther. 2009. PMID: 19887553 Free PMC article.

2

YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth.

Fotovati A, Abu-Ali S, Wang PS, Deleyrolle LP, Lee C, Triscott J, Chen JY, Franciosi S, Nakamura Y, Sugita Y, Uchiumi T, Kuwano M, Leavitt BR, Singh SK, Jury A, Jones C, Wakimoto H, Reynolds BA, Pallen CJ, Dunn SE. Fotovati A, et al. Cancer Res. 2011 Aug 15;71(16):5569-78. doi: 10.1158/0008-5472.CAN-10-2805. Epub 2011 Jul 5. Cancer Res. 2011. PMID: 21730024

3

Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells.

Hu K, Law JH, Fotovati A, Dunn SE. Hu K, et al. Among authors: fotovati a. Breast Cancer Res. 2012 Feb 6;14(1):R22. doi: 10.1186/bcr3107. Breast Cancer Res. 2012. PMID: 22309939 Free PMC article.

4

Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children.

Triscott J, Lee C, Foster C, Manoranjan B, Pambid MR, Berns R, Fotovati A, Venugopal C, O'Halloran K, Narendran A, Hawkins C, Ramaswamy V, Bouffet E, Taylor MD, Singhal A, Hukin J, Rassekh R, Yip S, Northcott P, Singh SK, Dunham C, Dunn SE. Triscott J, et al. Among authors: fotovati a. Cancer Res. 2013 Nov 15;73(22):6734-44. doi: 10.1158/0008-5472.CAN-12-4331. Epub 2013 Sep 9. Cancer Res. 2013. PMID: 24019381

5

Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent O6-methylguanine-DNA methyltransferase.

Gao Y, Fotovati A, Lee C, Wang M, Cote G, Guns E, Toyota B, Faury D, Jabado N, Dunn SE. Gao Y, et al. Among authors: fotovati a. Mol Cancer Ther. 2009 Dec;8(12):3276-84. doi: 10.1158/1535-7163.MCT-09-0478. Mol Cancer Ther. 2009. PMID: 19996271

6

Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells.

Finkbeiner MR, Astanehe A, To K, Fotovati A, Davies AH, Zhao Y, Jiang H, Stratford AL, Shadeo A, Boccaccio C, Comoglio P, Mertens PR, Eirew P, Raouf A, Eaves CJ, Dunn SE. Finkbeiner MR, et al. Among authors: fotovati a. Oncogene. 2009 Mar 19;28(11):1421-31. doi: 10.1038/onc.2008.485. Epub 2009 Jan 19. Oncogene. 2009. PMID: 19151767

7

The expression of activated Y-box binding protein-1 serine 102 mediates trastuzumab resistance in breast cancer cells by increasing CD44+ cells.

Dhillon J, Astanehe A, Lee C, Fotovati A, Hu K, Dunn SE. Dhillon J, et al. Among authors: fotovati a. Oncogene. 2010 Nov 25;29(47):6294-300. doi: 10.1038/onc.2010.365. Epub 2010 Aug 30. Oncogene. 2010. PMID: 20802512

8

Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice.

Lee C, Fotovati A, Triscott J, Chen J, Venugopal C, Singhal A, Dunham C, Kerr JM, Verreault M, Yip S, Wakimoto H, Jones C, Jayanthan A, Narendran A, Singh SK, Dunn SE. Lee C, et al. Among authors: fotovati a. Stem Cells. 2012 Jun;30(6):1064-75. doi: 10.1002/stem.1081. Stem Cells. 2012. PMID: 22415968

9

Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide.

Triscott J, Lee C, Hu K, Fotovati A, Berns R, Pambid M, Luk M, Kast RE, Kong E, Toyota E, Yip S, Toyota B, Dunn SE. Triscott J, et al. Among authors: fotovati a. Oncotarget. 2012 Oct;3(10):1112-23. doi: 10.18632/oncotarget.604. Oncotarget. 2012. PMID: 23047041 Free PMC article.

10

Tyrosine-kinase inhibition results in EGFR clustering at focal adhesions and consequent exocytosis in uPAR down-regulated cells of head and neck cancers.

Abu-Ali S, Fotovati A, Shirasuna K. Abu-Ali S, et al. Among authors: fotovati a. Mol Cancer. 2008 Jun 3;7:47. doi: 10.1186/1476-4598-7-47. Mol Cancer. 2008. PMID: 18519000 Free PMC article.

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