Patterson PH - Search Results

1

Intrabody gene therapy ameliorates motor, cognitive, and neuropathological symptoms in multiple mouse models of Huntington's disease.

Southwell AL, Ko J, Patterson PH. Southwell AL, et al. Among authors: patterson ph. J Neurosci. 2009 Oct 28;29(43):13589-602. doi: 10.1523/JNEUROSCI.4286-09.2009. J Neurosci. 2009. PMID: 19864571 Free PMC article.

2

Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.

Khoshnan A, Ko J, Watkin EE, Paige LA, Reinhart PH, Patterson PH. Khoshnan A, et al. Among authors: patterson ph. J Neurosci. 2004 Sep 15;24(37):7999-8008. doi: 10.1523/JNEUROSCI.2675-04.2004. J Neurosci. 2004. PMID: 15371500 Free PMC article.

3

Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity.

Southwell AL, Khoshnan A, Dunn DE, Bugg CW, Lo DC, Patterson PH. Southwell AL, et al. Among authors: patterson ph. J Neurosci. 2008 Sep 3;28(36):9013-20. doi: 10.1523/JNEUROSCI.2747-08.2008. J Neurosci. 2008. PMID: 18768695 Free PMC article.

4

Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1.

Southwell AL, Bugg CW, Kaltenbach LS, Dunn D, Butland S, Weiss A, Paganetti P, Lo DC, Patterson PH. Southwell AL, et al. Among authors: patterson ph. PLoS One. 2011 Jan 31;6(1):e16676. doi: 10.1371/journal.pone.0016676. PLoS One. 2011. PMID: 21304966 Free PMC article.

5

Gene therapy in mouse models of huntington disease.

Southwell AL, Patterson PH. Southwell AL, et al. Among authors: patterson ph. Neuroscientist. 2011 Apr;17(2):153-62. doi: 10.1177/1073858410386236. Neuroscientist. 2011. PMID: 21489966 Free PMC article. Review.

6

Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity.

Khoshnan A, Ko J, Patterson PH. Khoshnan A, et al. Among authors: patterson ph. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):1002-7. doi: 10.1073/pnas.022631799. Epub 2002 Jan 15. Proc Natl Acad Sci U S A. 2002. PMID: 11792860 Free PMC article.

7

Antibodies against huntingtin: production and screening of monoclonals and single-chain recombinant forms.

Khoshnan A, Ou S, Ko J, Patterson PH. Khoshnan A, et al. Among authors: patterson ph. Methods Mol Biol. 2004;277:87-102. doi: 10.1385/1-59259-804-8:087. Methods Mol Biol. 2004. PMID: 15201451

8

IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.

Khoshnan A, Ko J, Tescu S, Brundin P, Patterson PH. Khoshnan A, et al. Among authors: patterson ph. PLoS One. 2009 Jun 2;4(6):e5768. doi: 10.1371/journal.pone.0005768. PLoS One. 2009. PMID: 19488402 Free PMC article.

9

Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment.

Legleiter J, Lotz GP, Miller J, Ko J, Ng C, Williams GL, Finkbeiner S, Patterson PH, Muchowski PJ. Legleiter J, et al. Among authors: patterson ph. J Biol Chem. 2009 Aug 7;284(32):21647-58. doi: 10.1074/jbc.M109.016923. Epub 2009 Jun 2. J Biol Chem. 2009. PMID: 19491400 Free PMC article.

10

Antibody therapy in neurodegenerative disease.

Southwell AL, Patterson PH. Southwell AL, et al. Among authors: patterson ph. Rev Neurosci. 2010;21(4):273-87. doi: 10.1515/revneuro.2010.21.4.273. Rev Neurosci. 2010. PMID: 21086760 Free article.

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