Chiosis G - Search Results

1

Taldone T, Chiosis G. Taldone T, et al. Among authors: chiosis g. Curr Top Med Chem. 2009;9(15):1436-46. doi: 10.2174/156802609789895737. Curr Top Med Chem. 2009. PMID: 19860732 Free PMC article. Review.

2

LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family.

Chiosis G, Rosen N, Sepp-Lorenzino L. Chiosis G, et al. Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13. doi: 10.1016/s0960-894x(01)00099-3. Bioorg Med Chem Lett. 2001. PMID: 11294389

3

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells.

Chiosis G, Timaul MN, Lucas B, Munster PN, Zheng FF, Sepp-Lorenzino L, Rosen N. Chiosis G, et al. Chem Biol. 2001 Mar;8(3):289-99. doi: 10.1016/s1074-5521(01)00015-1. Chem Biol. 2001. PMID: 11306353

4

Facile synthesis of a library of 9-alkyl-8-benzyl-9H-purin-6-ylamine derivatives.

Lucas B, Rosen N, Chiosis G. Lucas B, et al. Among authors: chiosis g. J Comb Chem. 2001 Nov-Dec;3(6):518-20. doi: 10.1021/cc010017t. J Comb Chem. 2001. PMID: 11703144 No abstract available.

5

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.

Basso AD, Solit DB, Chiosis G, Giri B, Tsichlis P, Rosen N. Basso AD, et al. Among authors: chiosis g. J Biol Chem. 2002 Oct 18;277(42):39858-66. doi: 10.1074/jbc.M206322200. Epub 2002 Aug 9. J Biol Chem. 2002. PMID: 12176997 Free article.

6

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase.

Chiosis G, Lucas B, Shtil A, Huezo H, Rosen N. Chiosis G, et al. Bioorg Med Chem. 2002 Nov;10(11):3555-64. doi: 10.1016/s0968-0896(02)00253-5. Bioorg Med Chem. 2002. PMID: 12213470

7

Development of purine-scaffold small molecule inhibitors of Hsp90.

Chiosis G, Lucas B, Huezo H, Solit D, Basso A, Rosen N. Chiosis G, et al. Curr Cancer Drug Targets. 2003 Oct;3(5):371-6. doi: 10.2174/1568009033481778. Curr Cancer Drug Targets. 2003. PMID: 14529388 Review.

8

Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.

Llauger-Bufi L, Felts SJ, Huezo H, Rosen N, Chiosis G. Llauger-Bufi L, et al. Among authors: chiosis g. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3975-8. doi: 10.1016/j.bmcl.2003.08.065. Bioorg Med Chem Lett. 2003. PMID: 14592488

9

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

Vilenchik M, Solit D, Basso A, Huezo H, Lucas B, He H, Rosen N, Spampinato C, Modrich P, Chiosis G. Vilenchik M, et al. Among authors: chiosis g. Chem Biol. 2004 Jun;11(6):787-97. doi: 10.1016/j.chembiol.2004.04.008. Chem Biol. 2004. PMID: 15217612

10

Development of a fluorescence polarization assay for the molecular chaperone Hsp90.

Kim J, Felts S, Llauger L, He H, Huezo H, Rosen N, Chiosis G. Kim J, et al. Among authors: chiosis g. J Biomol Screen. 2004 Aug;9(5):375-81. doi: 10.1177/1087057104265995. J Biomol Screen. 2004. PMID: 15296636

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