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Page 1
Discovery of highly potent and selective type I B-Raf kinase inhibitors.
Wang X, Berger DM, Salaski EJ, Torres N, Hu Y, Levin JI, Powell D, Wojciechowicz D, Collins K, Frommer E. Wang X, et al. Among authors: powell d. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6571-4. doi: 10.1016/j.bmcl.2009.10.030. Epub 2009 Oct 13. Bioorg Med Chem Lett. 2009. PMID: 19854649
Synthesis and evaluation of 4-anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade.
Berger D, Dutia M, Powell D, Wu B, Wissner A, Boschelli DH, Floyd MB, Zhang N, Torres N, Levin J, Du X, Wojciechowicz D, Discafani C, Kohler C, Kim SC, Feldberg LR, Collins K, Mallon R. Berger D, et al. Among authors: powell d. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3031-4. doi: 10.1016/s0960-894x(03)00640-1. Bioorg Med Chem Lett. 2003. PMID: 12941327
4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors.
Berger DM, Dutia M, Powell D, Floyd MB, Torres N, Mallon R, Wojciechowicz D, Kim S, Feldberg L, Collins K, Chaudhary I. Berger DM, et al. Among authors: powell d. Bioorg Med Chem. 2008 Oct 15;16(20):9202-11. doi: 10.1016/j.bmc.2008.09.009. Epub 2008 Sep 9. Bioorg Med Chem. 2008. PMID: 18815050
Pyranonaphthoquinone lactones: a new class of AKT selective kinase inhibitors alkylate a regulatory loop cysteine.
Salaski EJ, Krishnamurthy G, Ding WD, Yu K, Insaf SS, Eid C, Shim J, Levin JI, Tabei K, Toral-Barza L, Zhang WG, McDonald LA, Honores E, Hanna C, Yamashita A, Johnson B, Li Z, Laakso L, Powell D, Mansour TS. Salaski EJ, et al. Among authors: powell d. J Med Chem. 2009 Apr 23;52(8):2181-4. doi: 10.1021/jm900075g. J Med Chem. 2009. PMID: 19309081
Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors.
Berger DM, Torres N, Dutia M, Powell D, Ciszewski G, Gopalsamy A, Levin JI, Kim KH, Xu W, Wilhelm J, Hu Y, Collins K, Feldberg L, Kim S, Frommer E, Wojciechowicz D, Mallon R. Berger DM, et al. Among authors: powell d. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23. doi: 10.1016/j.bmcl.2009.10.049. Epub 2009 Oct 26. Bioorg Med Chem Lett. 2009. PMID: 19864136
Novel pyrazolopyrimidines as highly potent B-Raf inhibitors.
Di Grandi MJ, Berger DM, Hopper DW, Zhang C, Dutia M, Dunnick AL, Torres N, Levin JI, Diamantidis G, Zapf CW, Bloom JD, Hu Y, Powell D, Wojciechowicz D, Collins K, Frommer E. Di Grandi MJ, et al. Among authors: powell d. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6957-61. doi: 10.1016/j.bmcl.2009.10.058. Epub 2009 Oct 28. Bioorg Med Chem Lett. 2009. PMID: 19875283
2,707 results