Hansell E - Search Results

1

Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases).

Ovat A, Muindi F, Fagan C, Brouner M, Hansell E, Dvorák J, Sojka D, Kopácek P, McKerrow JH, Caffrey CR, Powers JC. Ovat A, et al. Among authors: hansell e. J Med Chem. 2009 Nov 26;52(22):7192-210. doi: 10.1021/jm900849h. J Med Chem. 2009. PMID: 19848405

2

Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases).

James KE, Götz MG, Caffrey CR, Hansell E, Carter W, Barrett AJ, McKerrow JH, Powers JC. James KE, et al. Among authors: hansell e. Biol Chem. 2003 Dec;384(12):1613-8. doi: 10.1515/BC.2003.179. Biol Chem. 2003. PMID: 14719804

3

Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases.

Ekici OD, Götz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorák J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC. Ekici OD, et al. Among authors: hansell e. J Med Chem. 2004 Apr 8;47(8):1889-92. doi: 10.1021/jm049938j. J Med Chem. 2004. PMID: 15055989

4

Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases.

Götz MG, Caffrey CR, Hansell E, McKerrow JH, Powers JC. Götz MG, et al. Among authors: hansell e. Bioorg Med Chem. 2004 Oct 1;12(19):5203-11. doi: 10.1016/j.bmc.2004.07.016. Bioorg Med Chem. 2004. PMID: 15351403

5

Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens.

Götz MG, James KE, Hansell E, Dvorák J, Seshaadri A, Sojka D, Kopácek P, McKerrow JH, Caffrey CR, Powers JC. Götz MG, et al. Among authors: hansell e. J Med Chem. 2008 May 8;51(9):2816-32. doi: 10.1021/jm701311r. Epub 2008 Apr 17. J Med Chem. 2008. PMID: 18416543

6

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.

Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Fujii N, et al. Bioorg Med Chem Lett. 2005 Jan 3;15(1):121-3. doi: 10.1016/j.bmcl.2004.10.023. Bioorg Med Chem Lett. 2005. PMID: 15582423

7

Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.

Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE. Du X, et al. Among authors: hansell e. J Med Chem. 2002 Jun 20;45(13):2695-707. doi: 10.1021/jm010459j. J Med Chem. 2002. PMID: 12061873

8

Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents.

Vicik R, Hoerr V, Glaser M, Schultheis M, Hansell E, McKerrow JH, Holzgrabe U, Caffrey CR, Ponte-Sucre A, Moll H, Stich A, Schirmeister T. Vicik R, et al. Among authors: hansell e. Bioorg Med Chem Lett. 2006 May 15;16(10):2753-7. doi: 10.1016/j.bmcl.2006.02.026. Epub 2006 Mar 3. Bioorg Med Chem Lett. 2006. PMID: 16516467

9

Dipeptidyl-alpha,beta-epoxyesters as potent irreversible inhibitors of the cysteine proteases cruzain and rhodesain.

González FV, Izquierdo J, Rodríguez S, McKerrow JH, Hansell E. González FV, et al. Among authors: hansell e. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6697-700. doi: 10.1016/j.bmcl.2007.10.056. Epub 2007 Oct 22. Bioorg Med Chem Lett. 2007. PMID: 17977725

10

Synthesis of macrocyclic trypanosomal cysteine protease inhibitors.

Chen YT, Lira R, Hansell E, McKerrow JH, Roush WR. Chen YT, et al. Among authors: hansell e. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5860-3. doi: 10.1016/j.bmcl.2008.06.012. Epub 2008 Jun 10. Bioorg Med Chem Lett. 2008. PMID: 18585034 Free PMC article.

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