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8,139 results

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A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation.
Bodine PV, Stauffer B, Ponce-de-Leon H, Bhat RA, Mangine A, Seestaller-Wehr LM, Moran RA, Billiard J, Fukayama S, Komm BS, Pitts K, Krishnamurthy G, Gopalsamy A, Shi M, Kern JC, Commons TJ, Woodworth RP, Wilson MA, Welmaker GS, Trybulski EJ, Moore WJ. Bodine PV, et al. Among authors: shi m. Bone. 2009 Jun;44(6):1063-8. doi: 10.1016/j.bone.2009.02.013. Epub 2009 Feb 27. Bone. 2009. PMID: 19254787
Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.
Gopalsamy A, Shi M, Ciszewski G, Park K, Ellingboe JW, Orlowski M, Feld B, Howe AY. Gopalsamy A, et al. Among authors: shi m. Bioorg Med Chem Lett. 2006 May 1;16(9):2532-4. doi: 10.1016/j.bmcl.2006.01.105. Epub 2006 Feb 15. Bioorg Med Chem Lett. 2006. PMID: 16480869
Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.
Gopalsamy A, Chopra R, Lim K, Ciszewski G, Shi M, Curran KJ, Sukits SF, Svenson K, Bard J, Ellingboe JW, Agarwal A, Krishnamurthy G, Howe AY, Orlowski M, Feld B, O'Connell J, Mansour TS. Gopalsamy A, et al. Among authors: shi m. J Med Chem. 2006 Jun 1;49(11):3052-5. doi: 10.1021/jm060168g. J Med Chem. 2006. PMID: 16722622
Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
Gopalsamy A, Shi M, Golas J, Vogan E, Jacob J, Johnson M, Lee F, Nilakantan R, Petersen R, Svenson K, Chopra R, Tam MS, Wen Y, Ellingboe J, Arndt K, Boschelli F. Gopalsamy A, et al. Among authors: shi m. J Med Chem. 2008 Feb 14;51(3):373-5. doi: 10.1021/jm701385c. Epub 2008 Jan 16. J Med Chem. 2008. PMID: 18197612
Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors.
Gopalsamy A, Ciszewski G, Shi M, Berger D, Hu Y, Lee F, Feldberg L, Frommer E, Kim S, Collins K, Wojciechowicz D, Mallon R. Gopalsamy A, et al. Among authors: shi m. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6890-2. doi: 10.1016/j.bmcl.2009.10.074. Epub 2009 Oct 22. Bioorg Med Chem Lett. 2009. PMID: 19884006
B-Raf kinase inhibitors: hit enrichment through scaffold hopping.
Gopalsamy A, Shi M, Hu Y, Lee F, Feldberg L, Frommer E, Kim S, Collins K, Wojciechowicz D, Mallon R. Gopalsamy A, et al. Among authors: shi m. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2431-4. doi: 10.1016/j.bmcl.2010.03.030. Epub 2010 Mar 9. Bioorg Med Chem Lett. 2010. PMID: 20307980
8,139 results