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Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation.
Leighton MP, Nundlall S, Starborg T, Meadows RS, Suleman F, Knowles L, Wagener R, Thornton DJ, Kadler KE, Boot-Handford RP, Briggs MD. Leighton MP, et al. Among authors: briggs md. Hum Mol Genet. 2007 Jul 15;16(14):1728-41. doi: 10.1093/hmg/ddm121. Epub 2007 May 21. Hum Mol Genet. 2007. PMID: 17517694 Free PMC article.
Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP.
Piróg-Garcia KA, Meadows RS, Knowles L, Heinegård D, Thornton DJ, Kadler KE, Boot-Handford RP, Briggs MD. Piróg-Garcia KA, et al. Among authors: briggs md. Hum Mol Genet. 2007 Sep 1;16(17):2072-88. doi: 10.1093/hmg/ddm155. Epub 2007 Jun 22. Hum Mol Genet. 2007. PMID: 17588960 Free PMC article.
An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia.
Nundlall S, Rajpar MH, Bell PA, Clowes C, Zeeff LA, Gardner B, Thornton DJ, Boot-Handford RP, Briggs MD. Nundlall S, et al. Among authors: briggs md. Cell Stress Chaperones. 2010 Nov;15(6):835-49. doi: 10.1007/s12192-010-0193-y. Epub 2010 Apr 30. Cell Stress Chaperones. 2010. PMID: 20428984 Free PMC article.
76 results