Olofsson MH - Search Results

1

Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.

Fayad W, Fryknäs M, Brnjic S, Olofsson MH, Larsson R, Linder S. Fayad W, et al. Among authors: olofsson mh. PLoS One. 2009 Oct 2;4(10):e7238. doi: 10.1371/journal.pone.0007238. PLoS One. 2009. PMID: 19798419 Free PMC article.

2

Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model.

Fayad W, Brnjic S, Berglind D, Blixt S, Shoshan MC, Berndtsson M, Olofsson MH, Linder S. Fayad W, et al. Among authors: olofsson mh. Int J Cancer. 2009 Nov 15;125(10):2450-5. doi: 10.1002/ijc.24627. Int J Cancer. 2009. PMID: 19670329

3

Identification of agents that induce apoptosis of multicellular tumour spheroids: enrichment for mitotic inhibitors with hydrophobic properties.

Fayad W, Rickardson L, Haglund C, Olofsson MH, D'Arcy P, Larsson R, Linder S, Fryknäs M. Fayad W, et al. Among authors: olofsson mh. Chem Biol Drug Des. 2011 Oct;78(4):547-57. doi: 10.1111/j.1747-0285.2011.01170.x. Epub 2011 Jul 29. Chem Biol Drug Des. 2011. PMID: 21726416

4

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.

Hernlund E, Olofsson MH, Fayad W, Fryknäs M, Lesiak-Mieczkowska K, Zhang X, Brnjic S, Schmidt V, D'Arcy P, Sjöblom T, De Milito A, Larsson R, Linder S. Hernlund E, et al. Among authors: olofsson mh. Eur J Cancer. 2012 Feb;48(3):396-406. doi: 10.1016/j.ejca.2011.11.013. Epub 2011 Dec 7. Eur J Cancer. 2012. PMID: 22154651

5

Specific demonstration of drug-induced tumour cell apoptosis in human xenografts models using a plasma biomarker.

Olofsson MH, Cummings J, Fayad W, Brnjic S, Herrmann R, Berndtsson M, Hodgkinson C, Dean E, Odedra R, Wilkinson RW, Mundt KE, Busk M, Dive C, Linder S. Olofsson MH, et al. Cancer Biomark. 2009;5(3):117-25. doi: 10.3233/CBM-2009-0597. Cancer Biomark. 2009. PMID: 19407366

6

Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect?

Havelka AM, Berndtsson M, Olofsson MH, Shoshan MC, Linder S. Havelka AM, et al. Among authors: olofsson mh. Mini Rev Med Chem. 2007 Oct;7(10):1035-9. doi: 10.2174/138955707782110196. Mini Rev Med Chem. 2007. PMID: 17979806 Review.

7

Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II.

Olofsson MH, Havelka AM, Brnjic S, Shoshan MC, Linder S. Olofsson MH, et al. BMC Chem Biol. 2008 Aug 1;8:2. doi: 10.1186/1472-6769-8-2. BMC Chem Biol. 2008. PMID: 18673549 Free PMC article.

8

Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis.

Brnjic S, Olofsson MH, Havelka AM, Linder S. Brnjic S, et al. Among authors: olofsson mh. Mol Biosyst. 2010 May;6(5):767-74. doi: 10.1039/b920805d. Epub 2010 Feb 9. Mol Biosyst. 2010. PMID: 20567760 Review.

9

Inhibition of proteasome deubiquitinating activity as a new cancer therapy.

D'Arcy P, Brnjic S, Olofsson MH, Fryknäs M, Lindsten K, De Cesare M, Perego P, Sadeghi B, Hassan M, Larsson R, Linder S. D'Arcy P, et al. Among authors: olofsson mh. Nat Med. 2011 Nov 6;17(12):1636-40. doi: 10.1038/nm.2536. Nat Med. 2011. PMID: 22057347

10

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments.

Zhang X, Fryknäs M, Hernlund E, Fayad W, De Milito A, Olofsson MH, Gogvadze V, Dang L, Påhlman S, Schughart LA, Rickardson L, D'Arcy P, Gullbo J, Nygren P, Larsson R, Linder S. Zhang X, et al. Among authors: olofsson mh. Nat Commun. 2014;5:3295. doi: 10.1038/ncomms4295. Nat Commun. 2014. PMID: 24548894 Free PMC article.

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