Beeson D - Search Results

1

Selective DNAzyme-mediated cleavage of AChR mutant transcripts by targeting the mutation site or through mismatches in the binding arm.

Abdelgany A, Ealing J, Wood M, Beeson D. Abdelgany A, et al. Among authors: beeson d. J RNAi Gene Silencing. 2005 Jul 28;1(1):32-7. J RNAi Gene Silencing. 2005. PMID: 19771202 Free PMC article.

2

Mutations in congenital myasthenic syndromes reveal an epsilon subunit C-terminal cysteine, C470, crucial for maturation and surface expression of adult AChR.

Ealing J, Webster R, Brownlow S, Abdelgany A, Oosterhuis H, Muntoni F, Vaux DJ, Vincent A, Beeson D. Ealing J, et al. Among authors: beeson d. Hum Mol Genet. 2002 Nov 15;11(24):3087-96. doi: 10.1093/hmg/11.24.3087. Hum Mol Genet. 2002. PMID: 12417530

3

Therapeutic gene silencing in the nervous system.

Wood MJ, Trülzsch B, Abdelgany A, Beeson D. Wood MJ, et al. Among authors: beeson d. Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R279-84. doi: 10.1093/hmg/ddg275. Epub 2003 Aug 19. Hum Mol Genet. 2003. PMID: 12928477 Review.

4

Allele-specific silencing of a pathogenic mutant acetylcholine receptor subunit by RNA interference.

Abdelgany A, Wood M, Beeson D. Abdelgany A, et al. Among authors: beeson d. Hum Mol Genet. 2003 Oct 15;12(20):2637-44. doi: 10.1093/hmg/ddg280. Epub 2003 Aug 19. Hum Mol Genet. 2003. PMID: 12928480

5

Ribozymes and siRNA for the treatment of diseases of the nervous system.

Wood MJ, Trülzsch B, Abdelgany A, Beeson D. Wood MJ, et al. Among authors: beeson d. Curr Opin Mol Ther. 2003 Aug;5(4):383-8. Curr Opin Mol Ther. 2003. PMID: 14513681 Review.

6

Structural abnormalities of the AChR caused by mutations underlying congenital myasthenic syndromes.

Beeson D, Webster R, Ealing J, Croxen R, Brownlow S, Brydson M, Newsom-Davis J, Slater C, Hatton C, Shelley C, Colquhoun D, Vincent A. Beeson D, et al. Ann N Y Acad Sci. 2003 Sep;998:114-24. doi: 10.1196/annals.1254.013. Ann N Y Acad Sci. 2003. PMID: 14592868

7

Mutation in the AChR ion channel gate underlies a fast channel congenital myasthenic syndrome.

Webster R, Brydson M, Croxen R, Newsom-Davis J, Vincent A, Beeson D. Webster R, et al. Among authors: beeson d. Neurology. 2004 Apr 13;62(7):1090-6. doi: 10.1212/01.wnl.0000118205.99701.41. Neurology. 2004. PMID: 15079006

8

Hairpin DNAzymes: a new tool for efficient cellular gene silencing.

Abdelgany A, Wood M, Beeson D. Abdelgany A, et al. Among authors: beeson d. J Gene Med. 2007 Aug;9(8):727-38. doi: 10.1002/jgm.1061. J Gene Med. 2007. PMID: 17582227

9

Selective cleavage of AChR cRNAs harbouring mutations underlying the slow channel myasthenic syndrome by hammerhead ribozymes.

Abdelgany A, Ealing J, Wood M, Beeson D. Abdelgany A, et al. Among authors: beeson d. J RNAi Gene Silencing. 2005 Jul 28;1(1):26-31. J RNAi Gene Silencing. 2005. PMID: 19771201 Free PMC article.

10

Design of efficient DNAzymes against muscle AChR alpha-subunit cRNA in vitro and in HEK 293 cells.

Abdelgany A, Uddin MK, Wood M, Taira K, Beeson D. Abdelgany A, et al. Among authors: beeson d. J RNAi Gene Silencing. 2005 Oct 14;1(2):88-96. J RNAi Gene Silencing. 2005. PMID: 19771209 Free PMC article.

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