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Soluble guanylate cyclase-alpha1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia.
Vermeersch P, Buys E, Pokreisz P, Marsboom G, Ichinose F, Sips P, Pellens M, Gillijns H, Swinnen M, Graveline A, Collen D, Dewerchin M, Brouckaert P, Bloch KD, Janssens S. Vermeersch P, et al. Among authors: sips p. Circulation. 2007 Aug 21;116(8):936-43. doi: 10.1161/CIRCULATIONAHA.106.677245. Epub 2007 Aug 6. Circulation. 2007. PMID: 17679618
Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.
Thoonen R, Cauwels A, Decaluwe K, Geschka S, Tainsh RE, Delanghe J, Hochepied T, De Cauwer L, Rogge E, Voet S, Sips P, Karas RH, Bloch KD, Vuylsteke M, Stasch JP, Van de Voorde J, Buys ES, Brouckaert P. Thoonen R, et al. Among authors: sips p. Nat Commun. 2015 Oct 7;6:8482. doi: 10.1038/ncomms9482. Nat Commun. 2015. PMID: 26442659 Free PMC article.
Genetic modification of hypertension by sGCα1.
Sips PY, Buys ES. Sips PY, et al. Trends Cardiovasc Med. 2013 Nov;23(8):312-8. doi: 10.1016/j.tcm.2013.05.001. Epub 2013 Jun 5. Trends Cardiovasc Med. 2013. PMID: 23755896 Free PMC article. Review.
Androgen-sensitive hypertension associated with soluble guanylate cyclase-α1 deficiency is mediated by 20-HETE.
Dordea AC, Vandenwijngaert S, Garcia V, Tainsh RE, Nathan DI, Allen K, Raher MJ, Tainsh LT, Zhang F, Lieb WS, Mikelman S, Kirby A, Stevens C, Thoonen R, Hindle AG, Sips PY, Falck JR, Daly MJ, Brouckaert P, Bloch KD, Bloch DB, Malhotra R, Schwartzman ML, Buys ES. Dordea AC, et al. Among authors: sips py. Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1790-800. doi: 10.1152/ajpheart.00877.2015. Epub 2016 May 3. Am J Physiol Heart Circ Physiol. 2016. PMID: 27199131 Free PMC article.
53 results