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MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma.
van der Deen M, Taipaleenmäki H, Zhang Y, Teplyuk NM, Gupta A, Cinghu S, Shogren K, Maran A, Yaszemski MJ, Ling L, Cool SM, Leong DT, Dierkes C, Zustin J, Salto-Tellez M, Ito Y, Bae SC, Zielenska M, Squire JA, Lian JB, Stein JL, Zambetti GP, Jones SN, Galindo M, Hesse E, Stein GS, van Wijnen AJ. van der Deen M, et al. J Biol Chem. 2013 Jul 19;288(29):21307-21319. doi: 10.1074/jbc.M112.445890. Epub 2013 May 29. J Biol Chem. 2013. PMID: 23720736 Free PMC article.
Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility.
Leong DT, Lim J, Goh X, Pratap J, Pereira BP, Kwok HS, Nathan SS, Dobson JR, Lian JB, Ito Y, Voorhoeve PM, Stein GS, Salto-Tellez M, Cool SM, van Wijnen AJ. Leong DT, et al. Breast Cancer Res. 2010;12(5):R89. doi: 10.1186/bcr2762. Epub 2010 Oct 28. Breast Cancer Res. 2010. PMID: 21029421 Free PMC article.
RUNX3 functions as an oncogene in ovarian cancer.
Lee CW, Chuang LS, Kimura S, Lai SK, Ong CW, Yan B, Salto-Tellez M, Choolani M, Ito Y. Lee CW, et al. Gynecol Oncol. 2011 Aug;122(2):410-7. doi: 10.1016/j.ygyno.2011.04.044. Epub 2011 May 25. Gynecol Oncol. 2011. PMID: 21612813
328 results