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The anti-apoptotic protein BCL2L1/Bcl-xL is neutralized by pro-apoptotic PMAIP1/Noxa in neuroblastoma, thereby determining bortezomib sensitivity independent of prosurvival MCL1 expression.
Hagenbuchner J, Ausserlechner MJ, Porto V, David R, Meister B, Bodner M, Villunger A, Geiger K, Obexer P. Hagenbuchner J, et al. Among authors: porto v. J Biol Chem. 2010 Mar 5;285(10):6904-12. doi: 10.1074/jbc.M109.038331. Epub 2010 Jan 5. J Biol Chem. 2010. PMID: 20051518 Free PMC article.
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