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BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas.
Puxeddu E, Moretti S, Elisei R, Romei C, Pascucci R, Martinelli M, Marino C, Avenia N, Rossi ED, Fadda G, Cavaliere A, Ribacchi R, Falorni A, Pontecorvi A, Pacini F, Pinchera A, Santeusanio F. Puxeddu E, et al. Among authors: avenia n. J Clin Endocrinol Metab. 2004 May;89(5):2414-20. doi: 10.1210/jc.2003-031425. J Clin Endocrinol Metab. 2004. PMID: 15126572
Genotyping of an Italian papillary thyroid carcinoma cohort revealed high prevalence of BRAF mutations, absence of RAS mutations and allowed the detection of a new mutation of BRAF oncoprotein (BRAF(V599lns)).
Carta C, Moretti S, Passeri L, Barbi F, Avenia N, Cavaliere A, Monacelli M, Macchiarulo A, Santeusanio F, Tartaglia M, Puxeddu E. Carta C, et al. Among authors: avenia n. Clin Endocrinol (Oxf). 2006 Jan;64(1):105-9. doi: 10.1111/j.1365-2265.2005.02401.x. Clin Endocrinol (Oxf). 2006. PMID: 16402937
[Molecular medicine in thyroid surgery].
Moretti S, Barbi F, Tavano M, Calzolari F, Misso C, Lucchini R, Monacelli M, D'Ajello M, Puxeddu E, Avenia N. Moretti S, et al. Among authors: avenia n. Chir Ital. 2008 Mar-Apr;60(2):165-78. Chir Ital. 2008. PMID: 18689164 Review. Italian.
Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1.
Moretti S, Menicali E, Nucci N, Voce P, Colella R, Melillo RM, Liotti F, Morelli S, Fallarino F, Macchiarulo A, Santoro M, Avenia N, Puxeddu E. Moretti S, et al. Among authors: avenia n. J Biol Chem. 2017 Feb 3;292(5):1785-1797. doi: 10.1074/jbc.M116.745448. Epub 2016 Dec 19. J Biol Chem. 2017. PMID: 27994058 Free PMC article.
Clinical implications of BRAF mutation in thyroid carcinoma.
Puxeddu E, Durante C, Avenia N, Filetti S, Russo D. Puxeddu E, et al. Among authors: avenia n. Trends Endocrinol Metab. 2008 May-Jun;19(4):138-45. doi: 10.1016/j.tem.2007.12.003. Epub 2008 Mar 11. Trends Endocrinol Metab. 2008. PMID: 18337114 Review.
BRAF mutations in papillary thyroid carcinomas inhibit genes involved in iodine metabolism.
Durante C, Puxeddu E, Ferretti E, Morisi R, Moretti S, Bruno R, Barbi F, Avenia N, Scipioni A, Verrienti A, Tosi E, Cavaliere A, Gulino A, Filetti S, Russo D. Durante C, et al. Among authors: avenia n. J Clin Endocrinol Metab. 2007 Jul;92(7):2840-3. doi: 10.1210/jc.2006-2707. Epub 2007 May 8. J Clin Endocrinol Metab. 2007. PMID: 17488796
264 results