Wiertz EJ - Search Results

1

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.

Stagg HR, Thomas M, van den Boomen D, Wiertz EJ, Drabkin HA, Gemmill RM, Lehner PJ. Stagg HR, et al. Among authors: wiertz ej. J Cell Biol. 2009 Sep 7;186(5):685-92. doi: 10.1083/jcb.200906110. Epub 2009 Aug 31. J Cell Biol. 2009. PMID: 19720873 Free PMC article.

2

Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3.

Wang X, Herr RA, Chua WJ, Lybarger L, Wiertz EJ, Hansen TH. Wang X, et al. Among authors: wiertz ej. J Cell Biol. 2007 May 21;177(4):613-24. doi: 10.1083/jcb.200611063. Epub 2007 May 14. J Cell Biol. 2007. PMID: 17502423 Free PMC article.

3

The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex.

Verweij MC, Koppers-Lalic D, Loch S, Klauschies F, de la Salle H, Quinten E, Lehner PJ, Mulder A, Knittler MR, Tampé R, Koch J, Ressing ME, Wiertz EJ. Verweij MC, et al. Among authors: wiertz ej. J Immunol. 2008 Oct 1;181(7):4894-907. doi: 10.4049/jimmunol.181.7.4894. J Immunol. 2008. PMID: 18802093

4

Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates.

Wang X, Herr RA, Rabelink M, Hoeben RC, Wiertz EJ, Hansen TH. Wang X, et al. Among authors: wiertz ej. J Cell Biol. 2009 Nov 30;187(5):655-68. doi: 10.1083/jcb.200908036. J Cell Biol. 2009. PMID: 19951915 Free PMC article.

5

Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation.

van de Weijer ML, Schuren ABC, van den Boomen DJH, Mulder A, Claas FHJ, Lehner PJ, Lebbink RJ, Wiertz EJHJ. van de Weijer ML, et al. J Cell Sci. 2017 Sep 1;130(17):2883-2892. doi: 10.1242/jcs.206839. Epub 2017 Jul 25. J Cell Sci. 2017. PMID: 28743740 Free PMC article.

6

Ubiquitination is essential for human cytomegalovirus US11-mediated dislocation of MHC class I molecules from the endoplasmic reticulum to the cytosol.

Kikkert M, Hassink G, Barel M, Hirsch C, van der Wal FJ, Wiertz E. Kikkert M, et al. Biochem J. 2001 Sep 1;358(Pt 2):369-77. doi: 10.1042/0264-6021:3580369. Biochem J. 2001. PMID: 11513735 Free PMC article.

7

The Epstein-Barr virus G-protein-coupled receptor contributes to immune evasion by targeting MHC class I molecules for degradation.

Zuo J, Currin A, Griffin BD, Shannon-Lowe C, Thomas WA, Ressing ME, Wiertz EJ, Rowe M. Zuo J, et al. Among authors: wiertz ej. PLoS Pathog. 2009 Jan;5(1):e1000255. doi: 10.1371/journal.ppat.1000255. Epub 2009 Jan 2. PLoS Pathog. 2009. PMID: 19119421 Free PMC article.

8

Exploiting human herpesvirus immune evasion for therapeutic gain: potential and pitfalls.

Horst D, Ressing ME, Wiertz EJ. Horst D, et al. Among authors: wiertz ej. Immunol Cell Biol. 2011 Mar;89(3):359-66. doi: 10.1038/icb.2010.129. Epub 2011 Feb 8. Immunol Cell Biol. 2011. PMID: 21301483 Review.

9

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.

van de Weijer ML, Bassik MC, Luteijn RD, Voorburg CM, Lohuis MA, Kremmer E, Hoeben RC, LeProust EM, Chen S, Hoelen H, Ressing ME, Patena W, Weissman JS, McManus MT, Wiertz EJ, Lebbink RJ. van de Weijer ML, et al. Among authors: wiertz ej. Nat Commun. 2014 May 8;5:3832. doi: 10.1038/ncomms4832. Nat Commun. 2014. PMID: 24807418 Free PMC article.

10

Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.

van de Weijer ML, Krshnan L, Liberatori S, Guerrero EN, Robson-Tull J, Hahn L, Lebbink RJ, Wiertz EJHJ, Fischer R, Ebner D, Carvalho P. van de Weijer ML, et al. Among authors: wiertz ejhj. Mol Cell. 2020 Sep 3;79(5):768-781.e7. doi: 10.1016/j.molcel.2020.07.009. Epub 2020 Jul 31. Mol Cell. 2020. PMID: 32738194 Free PMC article.

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