Hashizume T - Search Results

1

Evaluation of the potential for drug-induced liver injury based on in vitro covalent binding to human liver proteins.

Usui T, Mise M, Hashizume T, Yabuki M, Komuro S. Usui T, et al. Among authors: hashizume t. Drug Metab Dispos. 2009 Dec;37(12):2383-92. doi: 10.1124/dmd.109.028860. Epub 2009 Aug 31. Drug Metab Dispos. 2009. PMID: 19720731

2

Characterization of substrate specificity of dog CYP1A2 using CYP1A2-deficient and wild-type dog liver microsomes.

Mise M, Hashizume T, Komuro S. Mise M, et al. Among authors: hashizume t. Drug Metab Dispos. 2008 Sep;36(9):1903-8. doi: 10.1124/dmd.108.022301. Epub 2008 Jun 23. Drug Metab Dispos. 2008. PMID: 18573860

3

In vitro investigation of the glutathione transferase M1 and T1 null genotypes as risk factors for troglitazone-induced liver injury.

Usui T, Hashizume T, Katsumata T, Yokoi T, Komuro S. Usui T, et al. Among authors: hashizume t. Drug Metab Dispos. 2011 Jul;39(7):1303-10. doi: 10.1124/dmd.111.038661. Epub 2011 Apr 21. Drug Metab Dispos. 2011. PMID: 21511944

4

Polymorphic expression of CYP1A2 leading to interindividual variability in metabolism of a novel benzodiazepine receptor partial inverse agonist in dogs.

Mise M, Yadera S, Matsuda M, Hashizume T, Matsumoto S, Terauchi Y, Fujii T. Mise M, et al. Among authors: hashizume t. Drug Metab Dispos. 2004 Feb;32(2):240-5. doi: 10.1124/dmd.32.2.240. Drug Metab Dispos. 2004. PMID: 14744947

5

N-Dealkylation and hydroxylation of ebastine by human liver cytochrome P450.

Hashizume T, Mise M, Terauchi Y, O L, Fujii T, Miyazaki H, Inaba T. Hashizume T, et al. Drug Metab Dispos. 1998 Jun;26(6):566-71. Drug Metab Dispos. 1998. PMID: 9616193

6

A novel cytochrome P450 enzyme responsible for the metabolism of ebastine in monkey small intestine.

Hashizume T, Mise M, Matsumoto S, Terauchi Y, Fujii T, Imaoka S, Funae Y, Kamataki T, Miyazaki H. Hashizume T, et al. Drug Metab Dispos. 2001 Jun;29(6):798-805. Drug Metab Dispos. 2001. PMID: 11353747

7

Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes.

Hashizume T, Imaoka S, Mise M, Terauchi Y, Fujii T, Miyazaki H, Kamataki T, Funae Y. Hashizume T, et al. J Pharmacol Exp Ther. 2002 Jan;300(1):298-304. doi: 10.1124/jpet.300.1.298. J Pharmacol Exp Ther. 2002. PMID: 11752129

8

Identification of non-functional allelic variant of CYP1A2 in dogs.

Mise M, Hashizume T, Matsumoto S, Terauchi Y, Fujii T. Mise M, et al. Among authors: hashizume t. Pharmacogenetics. 2004 Nov;14(11):769-73. doi: 10.1097/00008571-200411000-00008. Pharmacogenetics. 2004. PMID: 15564884

9

Blonanserin, a novel atypical antipsychotic agent not actively transported as substrate by P-glycoprotein.

Inoue T, Osada K, Tagawa M, Ogawa Y, Haga T, Sogame Y, Hashizume T, Watanabe T, Taguchi A, Katsumata T, Yabuki M, Yamaguchi N. Inoue T, et al. Among authors: hashizume t. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):156-62. doi: 10.1016/j.pnpbp.2012.06.005. Epub 2012 Jun 9. Prog Neuropsychopharmacol Biol Psychiatry. 2012. PMID: 22691713

10

Metabolic activation of benzodiazepines by CYP3A4.

Mizuno K, Katoh M, Okumura H, Nakagawa N, Negishi T, Hashizume T, Nakajima M, Yokoi T. Mizuno K, et al. Among authors: hashizume t. Drug Metab Dispos. 2009 Feb;37(2):345-51. doi: 10.1124/dmd.108.024521. Epub 2008 Nov 12. Drug Metab Dispos. 2009. PMID: 19005028

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