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In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.
McCahill A, McSorley T, Huston E, Hill EV, Lynch MJ, Gall I, Keryer G, Lygren B, Tasken K, van Heeke G, Houslay MD. McCahill A, et al. Among authors: tasken k. Cell Signal. 2005 Sep;17(9):1158-73. doi: 10.1016/j.cellsig.2005.04.003. Cell Signal. 2005. PMID: 15905070
Molecular basis of AKAP specificity for PKA regulatory subunits.
Gold MG, Lygren B, Dokurno P, Hoshi N, McConnachie G, Taskén K, Carlson CR, Scott JD, Barford D. Gold MG, et al. Among authors: tasken k. Mol Cell. 2006 Nov 3;24(3):383-95. doi: 10.1016/j.molcel.2006.09.006. Mol Cell. 2006. PMID: 17081989 Free article.
326 results