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Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I.
Dezfulian C, Shiva S, Alekseyenko A, Pendyal A, Beiser DG, Munasinghe JP, Anderson SA, Chesley CF, Vanden Hoek TL, Gladwin MT. Dezfulian C, et al. Circulation. 2009 Sep 8;120(10):897-905. doi: 10.1161/CIRCULATIONAHA.109.853267. Epub 2009 Aug 24. Circulation. 2009. PMID: 19704094 Free PMC article.
Metabolic Manipulation and Therapeutic Hypothermia.
Flickinger KL, Weissman A, Elmer J, Coppler PJ, Guyette FX, Repine MJ, Dezfulian C, Hopkins D, Frisch A, Doshi AA, Rittenberger JC, Callaway CW. Flickinger KL, et al. Among authors: dezfulian c. Ther Hypothermia Temp Manag. 2024 Mar;14(1):46-51. doi: 10.1089/ther.2023.0010. Epub 2023 Jul 3. Ther Hypothermia Temp Manag. 2024. PMID: 37405749
Nitrite therapy is neuroprotective and safe in cardiac arrest survivors.
Dezfulian C, Alekseyenko A, Dave KR, Raval AP, Do R, Kim F, Perez-Pinzon MA. Dezfulian C, et al. Nitric Oxide. 2012 May 15;26(4):241-50. doi: 10.1016/j.niox.2012.03.007. Epub 2012 Mar 30. Nitric Oxide. 2012. PMID: 22484664 Free PMC article. Clinical Trial.
Effects of inhalation of low-dose nitrite or carbon monoxide on post-reperfusion mitochondrial function and tissue injury in hemorrhagic shock swine.
Haugaa H, Gómez H, Maberry DR, Holder A, Ogundele O, Quintero AM, Escobar D, Tønnessen TI, Airgood H, Dezfulian C, Kenny E, Shiva S, Zuckerbraun B, Pinsky MR. Haugaa H, et al. Among authors: dezfulian c. Crit Care. 2015 Apr 22;19(1):184. doi: 10.1186/s13054-015-0903-z. Crit Care. 2015. PMID: 25899004 Free PMC article.
107 results