Aldern K - Search Results

1

Intravitreal crystalline drug delivery for intraocular proliferation diseases.

Cheng L, Hostetler K, Valiaeva N, Tammewar A, Freeman WR, Beadle J, Bartsch DU, Aldern K, Falkenstein I. Cheng L, et al. Among authors: aldern k. Invest Ophthalmol Vis Sci. 2010 Jan;51(1):474-81. doi: 10.1167/iovs.09-3672. Epub 2009 Aug 20. Invest Ophthalmol Vis Sci. 2010. PMID: 19696179 Free PMC article.

2

Characterization of a novel intraocular drug-delivery system using crystalline lipid antiviral prodrugs of ganciclovir and cyclic cidofovir.

Cheng L, Hostetler KY, Lee J, Koh HJ, Beadle JR, Bessho K, Toyoguchi M, Aldern K, Bovet JM, Freeman WR. Cheng L, et al. Among authors: aldern k. Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4138-44. doi: 10.1167/iovs.04-0064. Invest Ophthalmol Vis Sci. 2004. PMID: 15505067 Free PMC article.

3

Intraocular safety and pharmacokinetics of hexadecyloxypropyl-cidofovir (HDP-CDV) as a long-lasting intravitreal antiviral drug.

Wang H, Chhablani J, Freeman WR, Beadle JR, Hostetler KY, Hartmann K, Conner L, Aldern KA, Pearson L, Cheng L. Wang H, et al. Among authors: aldern ka. Invest Ophthalmol Vis Sci. 2011 Dec 9;52(13):9391-6. doi: 10.1167/iovs.11-8293. Invest Ophthalmol Vis Sci. 2011. PMID: 22058340 Free PMC article.

4

A novel cytarabine crystalline lipid prodrug: hexadecyloxypropyl cytarabine 3',5'-cyclic monophosphate for proliferative vitreoretinopathy.

Kim JS, Beadle JR, Freeman WR, Hostetler KY, Hartmann K, Valiaeva N, Kozak I, Conner L, Trahan J, Aldern KA, Cheng L. Kim JS, et al. Among authors: aldern ka. Mol Vis. 2012;18:1907-17. Epub 2012 Jul 14. Mol Vis. 2012. PMID: 22876115 Free PMC article.

5

Ganciclovir release rates in vitreous from different formulations of 1-O-hexadecylpropanediol-3-phospho-ganciclovir.

Cheng L, Hostetler KY, Toyoguchi M, Beadle JR, Rodanant N, Gardner MF, Aldern KA, Bergeron-Lynn G, Freeman WR. Cheng L, et al. J Ocul Pharmacol Ther. 2003 Apr;19(2):161-9. doi: 10.1089/108076803321637690. J Ocul Pharmacol Ther. 2003. PMID: 12804061

6

Synthesis and antiviral evaluation of alkoxyalkyl esters of acyclic purine and pyrimidine nucleoside phosphonates against HIV-1 in vitro.

Valiaeva N, Beadle JR, Aldern KA, Trahan J, Hostetler KY. Valiaeva N, et al. Antiviral Res. 2006 Oct;72(1):10-9. doi: 10.1016/j.antiviral.2006.03.007. Epub 2006 Apr 5. Antiviral Res. 2006. PMID: 16630664

7

Evaluation of a novel lipid prodrug for intraocular drug delivery: effect of acyclovir diphosphate dimyristoylglycerol in a rabbit model with herpes simplex virus-1 retinitis.

Taskintuna I, Banker AS, Flores-Aguilar M, Bergeron-Lynn G, Aldern KA, Hostetler KY, Freeman WR. Taskintuna I, et al. Among authors: aldern ka. Retina. 1997;17(1):57-64. doi: 10.1097/00006982-199701000-00011. Retina. 1997. PMID: 9051844

8

Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.

Ruiz JC, Beadle JR, Aldern KA, Keith KA, Hartline CB, Kern ER, Hostetler KY. Ruiz JC, et al. Among authors: aldern ka. Antiviral Res. 2007 Jul;75(1):87-90. doi: 10.1016/j.antiviral.2006.09.005. Epub 2006 Oct 10. Antiviral Res. 2007. PMID: 17367874 Free PMC article.

9

Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro.

Beadle JR, Hartline C, Aldern KA, Rodriguez N, Harden E, Kern ER, Hostetler KY. Beadle JR, et al. Antimicrob Agents Chemother. 2002 Aug;46(8):2381-6. doi: 10.1128/AAC.46.8.2381-2386.2002. Antimicrob Agents Chemother. 2002. PMID: 12121908 Free PMC article.

10

Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney.

Ciesla SL, Trahan J, Wan WB, Beadle JR, Aldern KA, Painter GR, Hostetler KY. Ciesla SL, et al. Antiviral Res. 2003 Aug;59(3):163-71. doi: 10.1016/s0166-3542(03)00110-4. Antiviral Res. 2003. PMID: 12927306

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