Smithgall TE - Search Results

1

N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor.

Choi Y, Seeliger MA, Panjarian SB, Kim H, Deng X, Sim T, Couch B, Koleske AJ, Smithgall TE, Gray NS. Choi Y, et al. Among authors: smithgall te. J Biol Chem. 2009 Oct 16;284(42):29005-14. doi: 10.1074/jbc.M109.026633. Epub 2009 Aug 13. J Biol Chem. 2009. PMID: 19679652 Free PMC article.

2

Conformational disturbance in Abl kinase upon mutation and deregulation.

Iacob RE, Pene-Dumitrescu T, Zhang J, Gray NS, Smithgall TE, Engen JR. Iacob RE, et al. Among authors: smithgall te. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1386-91. doi: 10.1073/pnas.0811912106. Epub 2009 Jan 21. Proc Natl Acad Sci U S A. 2009. PMID: 19164531 Free PMC article.

3

Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors.

Panjarian S, Iacob RE, Chen S, Wales TE, Engen JR, Smithgall TE. Panjarian S, et al. Among authors: smithgall te. J Biol Chem. 2013 Mar 1;288(9):6116-29. doi: 10.1074/jbc.M112.431312. Epub 2013 Jan 9. J Biol Chem. 2013. PMID: 23303187 Free PMC article.

4

Structure and dynamic regulation of Abl kinases.

Panjarian S, Iacob RE, Chen S, Engen JR, Smithgall TE. Panjarian S, et al. Among authors: smithgall te. J Biol Chem. 2013 Feb 22;288(8):5443-50. doi: 10.1074/jbc.R112.438382. Epub 2013 Jan 11. J Biol Chem. 2013. PMID: 23316053 Free PMC article. Review.

5

Small-molecule inhibitors of the c-Fes protein-tyrosine kinase.

Hellwig S, Miduturu CV, Kanda S, Zhang J, Filippakopoulos P, Salah E, Deng X, Choi HG, Zhou W, Hur W, Knapp S, Gray NS, Smithgall TE. Hellwig S, et al. Among authors: smithgall te. Chem Biol. 2012 Apr 20;19(4):529-40. doi: 10.1016/j.chembiol.2012.01.020. Chem Biol. 2012. PMID: 22520759 Free PMC article.

6

A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region.

Moroco JA, Baumgartner MP, Rust HL, Choi HG, Hur W, Gray NS, Camacho CJ, Smithgall TE. Moroco JA, et al. Among authors: smithgall te. Chem Biol Drug Des. 2015 Aug;86(2):144-55. doi: 10.1111/cbdd.12473. Epub 2014 Nov 28. Chem Biol Drug Des. 2015. PMID: 25376742 Free PMC article.

7

c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution.

Badger J, Grover P, Shi H, Panjarian SB, Engen JR, Smithgall TE, Makowski L. Badger J, et al. Among authors: smithgall te. Biochemistry. 2016 Jun 14;55(23):3251-60. doi: 10.1021/acs.biochem.6b00202. Epub 2016 Jun 3. Biochemistry. 2016. PMID: 27166638 Free PMC article.

8

Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD+ AML cell growth.

Weir MC, Hellwig S, Tan L, Liu Y, Gray NS, Smithgall TE. Weir MC, et al. Among authors: smithgall te. PLoS One. 2017 Jul 20;12(7):e0181178. doi: 10.1371/journal.pone.0181178. eCollection 2017. PLoS One. 2017. PMID: 28727840 Free PMC article.

9

Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo.

Weir MC, Shu ST, Patel RK, Hellwig S, Chen L, Tan L, Gray NS, Smithgall TE. Weir MC, et al. Among authors: smithgall te. ACS Chem Biol. 2018 Jun 15;13(6):1551-1559. doi: 10.1021/acschembio.8b00154. Epub 2018 May 30. ACS Chem Biol. 2018. PMID: 29763550 Free PMC article.

10

Activation of STAT3 by the c-Fes protein-tyrosine kinase.

Nelson KL, Rogers JA, Bowman TL, Jove R, Smithgall TE. Nelson KL, et al. Among authors: smithgall te. J Biol Chem. 1998 Mar 20;273(12):7072-7. doi: 10.1074/jbc.273.12.7072. J Biol Chem. 1998. PMID: 9507017 Free article.

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