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Immunization with DNA vaccines containing porcine reproductive and respiratory syndrome virus open reading frames 5, 6, and 7 may be related to the exacerbation of clinical disease after an experimental challenge.
Díaz I, Ganges L, Galindo-Cardiel I, Tarradas J, Alvarez B, Lorca-Oró C, Pujols J, Gimeno M, Darwich L, Domingo M, Domínguez J, Mateu E. Díaz I, et al. Among authors: gimeno m. Viral Immunol. 2013 Feb;26(1):93-101. doi: 10.1089/vim.2012.0041. Viral Immunol. 2013. PMID: 23409932
Effects of challenge with a virulent genotype II strain of porcine reproductive and respiratory syndrome virus on piglets vaccinated with an attenuated genotype I strain vaccine.
Roca M, Gimeno M, Bruguera S, Segalés J, Díaz I, Galindo-Cardiel IJ, Martínez E, Darwich L, Fang Y, Maldonado J, March R, Mateu E. Roca M, et al. Among authors: gimeno m. Vet J. 2012 Jul;193(1):92-6. doi: 10.1016/j.tvjl.2011.11.019. Epub 2012 Jan 20. Vet J. 2012. PMID: 22264642 Clinical Trial.
657 results