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Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice.
Bhandarkar SS, Jaconi M, Fried LE, Bonner MY, Lefkove B, Govindarajan B, Perry BN, Parhar R, Mackelfresh J, Sohn A, Stouffs M, Knaus U, Yancopoulos G, Reiss Y, Benest AV, Augustin HG, Arbiser JL. Bhandarkar SS, et al. Among authors: yancopoulos g. J Clin Invest. 2009 Aug;119(8):2359-65. doi: 10.1172/JCI33877. Epub 2009 Jul 13. J Clin Invest. 2009. PMID: 19620773 Free PMC article.
Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice.
Perry BN, Govindarajan B, Bhandarkar SS, Knaus UG, Valo M, Sturk C, Carrillo CO, Sohn A, Cerimele F, Dumont D, Losken A, Williams J, Brown LF, Tan X, Ioffe E, Yancopoulos GD, Arbiser JL. Perry BN, et al. Among authors: yancopoulos gd. J Invest Dermatol. 2006 Oct;126(10):2316-22. doi: 10.1038/sj.jid.5700413. Epub 2006 Jun 1. J Invest Dermatol. 2006. PMID: 16741507 Free article.
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors.
Shmelkov SV, Butler JM, Hooper AT, Hormigo A, Kushner J, Milde T, St Clair R, Baljevic M, White I, Jin DK, Chadburn A, Murphy AJ, Valenzuela DM, Gale NW, Thurston G, Yancopoulos GD, D'Angelica M, Kemeny N, Lyden D, Rafii S. Shmelkov SV, et al. Among authors: yancopoulos gd. J Clin Invest. 2008 Jun;118(6):2111-20. doi: 10.1172/JCI34401. J Clin Invest. 2008. PMID: 18497886 Free PMC article.
TLR8 deficiency leads to autoimmunity in mice.
Demaria O, Pagni PP, Traub S, de Gassart A, Branzk N, Murphy AJ, Valenzuela DM, Yancopoulos GD, Flavell RA, Alexopoulou L. Demaria O, et al. J Clin Invest. 2010 Oct;120(10):3651-62. doi: 10.1172/JCI42081. Epub 2010 Sep 1. J Clin Invest. 2010. PMID: 20811154 Free PMC article.
Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells.
Daly C, Pasnikowski E, Burova E, Wong V, Aldrich TH, Griffiths J, Ioffe E, Daly TJ, Fandl JP, Papadopoulos N, McDonald DM, Thurston G, Yancopoulos GD, Rudge JS. Daly C, et al. Among authors: yancopoulos gd. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15491-6. doi: 10.1073/pnas.0607538103. Epub 2006 Oct 9. Proc Natl Acad Sci U S A. 2006. PMID: 17030814 Free PMC article.
504 results