Auton M - Search Results

1

Changes in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIbalpha.

Auton M, Sedlák E, Marek J, Wu T, Zhu C, Cruz MA. Auton M, et al. Biophys J. 2009 Jul 22;97(2):618-27. doi: 10.1016/j.bpj.2009.05.009. Biophys J. 2009. PMID: 19619477 Free PMC article.

2

Wedging the door open on platelet-type von Willebrand disease.

Auton M, Tischer A. Auton M, et al. Br J Haematol. 2023 Nov;203(4):501-503. doi: 10.1111/bjh.19094. Epub 2023 Sep 4. Br J Haematol. 2023. PMID: 37666663 No abstract available.

3

Conformational stability and domain unfolding of the Von Willebrand factor A domains.

Auton M, Cruz MA, Moake J. Auton M, et al. J Mol Biol. 2007 Feb 23;366(3):986-1000. doi: 10.1016/j.jmb.2006.10.067. Epub 2006 Oct 25. J Mol Biol. 2007. PMID: 17187823

4

Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress.

Auton M, Sowa KE, Smith SM, Sedlák E, Vijayan KV, Cruz MA. Auton M, et al. J Biol Chem. 2010 Jul 23;285(30):22831-9. doi: 10.1074/jbc.M110.103358. Epub 2010 May 24. J Biol Chem. 2010. PMID: 20498367 Free PMC article.

5

The mechanism of VWF-mediated platelet GPIbalpha binding.

Auton M, Zhu C, Cruz MA. Auton M, et al. Biophys J. 2010 Aug 9;99(4):1192-201. doi: 10.1016/j.bpj.2010.06.002. Biophys J. 2010. PMID: 20713003 Free PMC article.

6

Osmolyte effects on protein stability and solubility: a balancing act between backbone and side-chains.

Auton M, Rösgen J, Sinev M, Holthauzen LM, Bolen DW. Auton M, et al. Biophys Chem. 2011 Nov;159(1):90-9. doi: 10.1016/j.bpc.2011.05.012. Epub 2011 May 19. Biophys Chem. 2011. PMID: 21683504 Free PMC article.

7

N-terminal flanking region of A1 domain in von Willebrand factor stabilizes structure of A1A2A3 complex and modulates platelet activation under shear stress.

Auton M, Sowa KE, Behymer M, Cruz MA. Auton M, et al. J Biol Chem. 2012 Apr 27;287(18):14579-85. doi: 10.1074/jbc.M112.348573. Epub 2012 Mar 19. J Biol Chem. 2012. PMID: 22431729 Free PMC article. Clinical Trial.

8

The linker between the D3 and A1 domains of vWF suppresses A1-GPIbα catch bonds by site-specific binding to the A1 domain.

Tischer A, Cruz MA, Auton M. Tischer A, et al. Among authors: auton m. Protein Sci. 2013 Aug;22(8):1049-59. doi: 10.1002/pro.2294. Protein Sci. 2013. PMID: 23775931 Free PMC article.

9

Misfolding of vWF to pathologically disordered conformations impacts the severity of von Willebrand disease.

Tischer A, Madde P, Moon-Tasson L, Auton M. Tischer A, et al. Among authors: auton m. Biophys J. 2014 Sep 2;107(5):1185-1195. doi: 10.1016/j.bpj.2014.07.026. Biophys J. 2014. PMID: 25185554 Free PMC article.

10

Structural origins of misfolding propensity in the platelet adhesive von Willebrand factor A1 domain.

Zimmermann MT, Tischer A, Whitten ST, Auton M. Zimmermann MT, et al. Among authors: auton m. Biophys J. 2015 Jul 21;109(2):398-406. doi: 10.1016/j.bpj.2015.06.008. Biophys J. 2015. PMID: 26200876 Free PMC article.

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