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Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine decarboxylase and IL-4 gene transcriptions.
Shahriar M, Mizuguchi H, Maeyama K, Kitamura Y, Orimoto N, Horio S, Umehara H, Hattori M, Takeda N, Fukui H. Shahriar M, et al. Among authors: umehara h. J Immunol. 2009 Aug 1;183(3):2133-41. doi: 10.4049/jimmunol.0901058. Epub 2009 Jul 13. J Immunol. 2009. PMID: 19596986
Repeated pre-treatment with antihistamines suppresses [corrected] transcriptional up-regulations of histamine H(1) receptor and interleukin-4 genes in toluene-2,4-diisocyanate-sensitized rats.
Mizuguchi H, Hatano M, Matsushita C, Umehara H, Kuroda W, Kitamura Y, Takeda N, Fukui H. Mizuguchi H, et al. Among authors: umehara h. J Pharmacol Sci. 2008 Dec;108(4):480-6. doi: 10.1254/jphs.08222fp. Epub 2008 Dec 10. J Pharmacol Sci. 2008. PMID: 19075512 Free article.
Deprivation of anticipated food under scheduled feeding induces c-Fos expression in the caudal part of the arcuate nucleus of hypothalamus through histamine H₁ receptors in rats: potential involvement of E3 subgroup of histaminergic neurons in tuberomammillary nucleus.
Umehara H, Mizuguchi H, Mizukawa N, Matsumoto M, Takeda N, Senba E, Fukui H. Umehara H, et al. Brain Res. 2011 Apr 28;1387:61-70. doi: 10.1016/j.brainres.2011.02.018. Epub 2011 Feb 12. Brain Res. 2011. PMID: 21320473
293 results