Wetzel R - Search Results

1

Common threads in neurodegenerative disorders of aging.

Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, Wetzel R, Wexler NS, Young AB, Bain L. Beal MF, et al. Among authors: wetzel r. Alzheimers Dement. 2006 Oct;2(4):322-6. doi: 10.1016/j.jalz.2006.08.008. Alzheimers Dement. 2006. PMID: 19595906 No abstract available.

2

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.

Gu X, Greiner ER, Mishra R, Kodali R, Osmand A, Finkbeiner S, Steffan JS, Thompson LM, Wetzel R, Yang XW. Gu X, et al. Among authors: wetzel r. Neuron. 2009 Dec 24;64(6):828-40. doi: 10.1016/j.neuron.2009.11.020. Neuron. 2009. PMID: 20064390 Free PMC article.

3

Normal-repeat-length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins.

Slepko N, Bhattacharyya AM, Jackson GR, Steffan JS, Marsh JL, Thompson LM, Wetzel R. Slepko N, et al. Among authors: wetzel r. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14367-72. doi: 10.1073/pnas.0602348103. Epub 2006 Sep 15. Proc Natl Acad Sci U S A. 2006. PMID: 16980414 Free PMC article.

4

Aggregation behavior of chemically synthesized, full-length huntingtin exon1.

Sahoo B, Singer D, Kodali R, Zuchner T, Wetzel R. Sahoo B, et al. Among authors: wetzel r. Biochemistry. 2014 Jun 24;53(24):3897-907. doi: 10.1021/bi500300c. Epub 2014 Jun 12. Biochemistry. 2014. PMID: 24921664 Free PMC article.

5

Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments.

Jayaraman M, Kodali R, Sahoo B, Thakur AK, Mayasundari A, Mishra R, Peterson CB, Wetzel R. Jayaraman M, et al. Among authors: wetzel r. J Mol Biol. 2012 Feb 3;415(5):881-99. doi: 10.1016/j.jmb.2011.12.010. Epub 2011 Dec 9. J Mol Biol. 2012. PMID: 22178474 Free PMC article.

6

Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties.

Jayaraman M, Mishra R, Kodali R, Thakur AK, Koharudin LM, Gronenborn AM, Wetzel R. Jayaraman M, et al. Among authors: wetzel r. Biochemistry. 2012 Apr 3;51(13):2706-16. doi: 10.1021/bi3000929. Epub 2012 Mar 20. Biochemistry. 2012. PMID: 22432740 Free PMC article.

7

Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties.

Mishra R, Hoop CL, Kodali R, Sahoo B, van der Wel PC, Wetzel R. Mishra R, et al. Among authors: wetzel r. J Mol Biol. 2012 Nov 23;424(1-2):1-14. doi: 10.1016/j.jmb.2012.09.011. Epub 2012 Sep 18. J Mol Biol. 2012. PMID: 22999956 Free PMC article.

8

Inhibiting the nucleation of amyloid structure in a huntingtin fragment by targeting α-helix-rich oligomeric intermediates.

Mishra R, Jayaraman M, Roland BP, Landrum E, Fullam T, Kodali R, Thakur AK, Arduini I, Wetzel R. Mishra R, et al. Among authors: wetzel r. J Mol Biol. 2012 Feb 3;415(5):900-17. doi: 10.1016/j.jmb.2011.12.011. Epub 2011 Dec 9. J Mol Biol. 2012. PMID: 22178478 Free PMC article.

9

A serendipitous survey of prediction algorithms for amyloidogenicity.

Roland BP, Kodali R, Mishra R, Wetzel R. Roland BP, et al. Among authors: wetzel r. Biopolymers. 2013 Nov;100(6):780-9. doi: 10.1002/bip.22305. Biopolymers. 2013. PMID: 23893755 Free PMC article.

10

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism.

Thakur AK, Jayaraman M, Mishra R, Thakur M, Chellgren VM, Byeon IJ, Anjum DH, Kodali R, Creamer TP, Conway JF, Gronenborn AM, Wetzel R. Thakur AK, et al. Among authors: wetzel r. Nat Struct Mol Biol. 2009 Apr;16(4):380-9. doi: 10.1038/nsmb.1570. Epub 2009 Mar 8. Nat Struct Mol Biol. 2009. PMID: 19270701 Free PMC article.

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