Hirao Y - Search Results

1

Desirable pharmacokinetic properties of (13)C-uracil as a breath test probe of gastric emptying in comparison with (13)C-acetate and (13)C-octanoate in rats.

Sugiyama E, Inada M, Kunizaki J, Tobita K, Yoshida T, Kashimoto M, Hirao Y, Sato H. Sugiyama E, et al. Among authors: hirao y. Scand J Gastroenterol. 2009;44(9):1067-75. doi: 10.1080/00365520903114904. Scand J Gastroenterol. 2009. PMID: 19585373

2

Physiologically based pharmacokinetic modelling of the three-step metabolism of pyrimidine using C-uracil as an in vivo probe.

Ito S, Kawamura T, Inada M, Inoue Y, Hirao Y, Koga T, Kunizaki J, Shimizu T, Sato H. Ito S, et al. Among authors: hirao y. Br J Clin Pharmacol. 2005 Dec;60(6):584-93. doi: 10.1111/j.1365-2125.2005.02472.x. Br J Clin Pharmacol. 2005. PMID: 16305582 Free PMC article.

3

Pharmacokinetic modelling of [2-13C]uracil metabolism in normal and DPD-deficient dogs.

Inada M, Hirao Y, Koga T, Itose M, Kunizaki J, Shimizu T, Sato H. Inada M, et al. Among authors: hirao y. Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1205-9. doi: 10.1080/15257770600894550. Nucleosides Nucleotides Nucleic Acids. 2006. PMID: 17065092

4

Relationships among plasma [2-(13)C]uracil concentrations, breath (13)CO(2) expiration, and dihydropyrimidine dehydrogenase (DPD) activity in the liver in normal and dpd-deficient dogs.

Inada M, Hirao Y, Koga T, Itose M, Kunizaki J, Shimizu T, Sato H. Inada M, et al. Among authors: hirao y. Drug Metab Dispos. 2005 Mar;33(3):381-7. doi: 10.1124/dmd.104.001032. Epub 2004 Dec 22. Drug Metab Dispos. 2005. PMID: 15616154

5

The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity: pharmacokinetic relationship between expired 13CO2 and plasma [2-13C]dihydrouracil.

Mattison LK, Fourie J, Hirao Y, Koga T, Desmond RA, King JR, Shimizu T, Diasio RB. Mattison LK, et al. Among authors: hirao y. Clin Cancer Res. 2006 Jan 15;12(2):549-55. doi: 10.1158/1078-0432.CCR-05-2020. Clin Cancer Res. 2006. PMID: 16428499

6

Liquid chromatography-tandem mass spectrometry method for determining tolvaptan and its nine metabolites in rat serum: application to a pharmacokinetic study.

Furukawa M, Miyata K, Kawasome C, Himeda Y, Takeuchi K, Koga T, Hirao Y, Umehara K. Furukawa M, et al. Among authors: hirao y. Arch Pharm Res. 2014 Dec;37(12):1578-87. doi: 10.1007/s12272-014-0352-2. Epub 2014 Mar 24. Arch Pharm Res. 2014. PMID: 24988986

7

In vitro characterization of the oxidative cleavage of the octyl side chain of olanexidine, a novel antimicrobial agent, in dog liver microsomes.

Umehara K, Kudo S, Hirao Y, Morita S, Ohtani T, Uchida M, Miyamoto G. Umehara K, et al. Among authors: hirao y. Drug Metab Dispos. 2000 Dec;28(12):1417-24. Drug Metab Dispos. 2000. PMID: 11095578

8

Oxidative cleavage of the octyl side chain of 1-(3,4-dichlorobenzyl)-5-octylbiguanide (OPB-2045) in rat and dog liver preparations.

Umehara K, Kudo S, Hirao Y, Morita S, Uchida M, Odomi M, Miyamoto G. Umehara K, et al. Among authors: hirao y. Drug Metab Dispos. 2000 Aug;28(8):887-94. Drug Metab Dispos. 2000. PMID: 10901696

9

Pharmacokinetics and Metabolism of Delamanid, a Novel Anti-Tuberculosis Drug, in Animals and Humans: Importance of Albumin Metabolism In Vivo.

Sasahara K, Shimokawa Y, Hirao Y, Koyama N, Kitano K, Shibata M, Umehara K. Sasahara K, et al. Among authors: hirao y. Drug Metab Dispos. 2015 Aug;43(8):1267-76. doi: 10.1124/dmd.115.064527. Epub 2015 Jun 8. Drug Metab Dispos. 2015. PMID: 26055620

10

Pharmacokinetics and metabolism of brexpiprazole, a novel serotonin-dopamine activity modulator and its main metabolite in rat, monkey and human.

Sasabe H, Koga T, Furukawa M, Matsunaga M, Kaneko Y, Koyama N, Hirao Y, Akazawa H, Kawabata M, Kashiyama E, Takeuchi K. Sasabe H, et al. Among authors: hirao y. Xenobiotica. 2021 May;51(5):590-604. doi: 10.1080/00498254.2021.1890275. Epub 2021 Mar 9. Xenobiotica. 2021. PMID: 33685346

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