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Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.
Feisst C, Pergola C, Rakonjac M, Rossi A, Koeberle A, Dodt G, Hoffmann M, Hoernig C, Fischer L, Steinhilber D, Franke L, Schneider G, Rådmark O, Sautebin L, Werz O. Feisst C, et al. Among authors: hoernig c. Cell Mol Life Sci. 2009 Aug;66(16):2759-71. doi: 10.1007/s00018-009-0078-3. Epub 2009 Jul 5. Cell Mol Life Sci. 2009. PMID: 19579006 Free PMC article.
The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Koeberle A, Rossi A, Zettl H, Pergola C, Dehm F, Bauer J, Greiner C, Reckel S, Hoernig C, Northoff H, Bernhard F, Dötsch V, Sautebin L, Schubert-Zsilavecz M, Werz O. Koeberle A, et al. Among authors: hoernig c. J Pharmacol Exp Ther. 2010 Mar;332(3):840-8. doi: 10.1124/jpet.109.160663. Epub 2009 Nov 24. J Pharmacol Exp Ther. 2010. PMID: 19934399