Schofield CJ - Search Results

1

Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing.

Webby CJ, Wolf A, Gromak N, Dreger M, Kramer H, Kessler B, Nielsen ML, Schmitz C, Butler DS, Yates JR 3rd, Delahunty CM, Hahn P, Lengeling A, Mann M, Proudfoot NJ, Schofield CJ, Böttger A. Webby CJ, et al. Among authors: schofield cj. Science. 2009 Jul 3;325(5936):90-3. doi: 10.1126/science.1175865. Science. 2009. PMID: 19574390 Free article.

2

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ. Jaakkola P, et al. Among authors: schofield cj. Science. 2001 Apr 20;292(5516):468-72. doi: 10.1126/science.1059796. Epub 2001 Apr 5. Science. 2001. PMID: 11292861

3

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.

McNeill LA, Hewitson KS, Claridge TD, Seibel JF, Horsfall LE, Schofield CJ. McNeill LA, et al. Among authors: schofield cj. Biochem J. 2002 Nov 1;367(Pt 3):571-5. doi: 10.1042/BJ20021162. Biochem J. 2002. PMID: 12215170 Free PMC article.

4

Studies on the specificity of unprocessed and mature forms of phytanoyl-CoA 2-hydroxylase and mutation of the iron binding ligands.

Searls T, Butler D, Chien W, Mukherji M, Lloyd MD, Schofield CJ. Searls T, et al. Among authors: schofield cj. J Lipid Res. 2005 Aug;46(8):1660-7. doi: 10.1194/jlr.M500034-JLR200. Epub 2005 Jun 1. J Lipid Res. 2005. PMID: 15930519 Free article.

5

Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.

McDonough MA, Kavanagh KL, Butler D, Searls T, Oppermann U, Schofield CJ. McDonough MA, et al. Among authors: schofield cj. J Biol Chem. 2005 Dec 9;280(49):41101-10. doi: 10.1074/jbc.M507528200. Epub 2005 Sep 25. J Biol Chem. 2005. PMID: 16186124 Free article.

6

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.

Hewitson KS, Liénard BM, McDonough MA, Clifton IJ, Butler D, Soares AS, Oldham NJ, McNeill LA, Schofield CJ. Hewitson KS, et al. Among authors: schofield cj. J Biol Chem. 2007 Feb 2;282(5):3293-301. doi: 10.1074/jbc.M608337200. Epub 2006 Nov 29. J Biol Chem. 2007. PMID: 17135241 Free article.

7

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.

Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ. Coleman ML, et al. Among authors: schofield cj. J Biol Chem. 2007 Aug 17;282(33):24027-38. doi: 10.1074/jbc.M704102200. Epub 2007 Jun 15. J Biol Chem. 2007. PMID: 17573339 Free article.

8

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U. Ng SS, et al. Among authors: schofield cj. Nature. 2007 Jul 5;448(7149):87-91. doi: 10.1038/nature05971. Epub 2007 Jun 24. Nature. 2007. PMID: 17589501

9

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ. Gerken T, et al. Among authors: schofield cj. Science. 2007 Nov 30;318(5855):1469-72. doi: 10.1126/science.1151710. Epub 2007 Nov 8. Science. 2007. PMID: 17991826 Free PMC article.

10

Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily.

Batchelar ET, Hamed RB, Ducho C, Claridge TD, Edelmann MJ, Kessler B, Schofield CJ. Batchelar ET, et al. Among authors: schofield cj. Angew Chem Int Ed Engl. 2008;47(48):9322-5. doi: 10.1002/anie.200803906. Angew Chem Int Ed Engl. 2008. PMID: 18972478 No abstract available.

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