Muthas D - Search Results

1

Functionalized 3-amino-imidazo[1,2-a]pyridines: a novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors.

Odell LR, Nilsson MT, Gising J, Lagerlund O, Muthas D, Nordqvist A, Karlén A, Larhed M. Odell LR, et al. Among authors: muthas d. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4790-3. doi: 10.1016/j.bmcl.2009.06.045. Epub 2009 Jun 14. Bioorg Med Chem Lett. 2009. PMID: 19560924

2

Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II.

Muthas D, Nöteberg D, Sabnis YA, Hamelink E, Vrang L, Samuelsson B, Karlén A, Hallberg A. Muthas D, et al. Bioorg Med Chem. 2005 Sep 15;13(18):5371-90. doi: 10.1016/j.bmc.2005.06.048. Bioorg Med Chem. 2005. PMID: 16054370

3

Novel pseudopeptides incorporating a benzodiazepine-based turn mimetic--targeting Mycobacterium tuberculosis ribonucleotide reductase.

Nurbo J, Ericsson DJ, Rosenström U, Muthas D, Jansson AM, Lindeberg G, Unge T, Karlén A. Nurbo J, et al. Among authors: muthas d. Bioorg Med Chem. 2013 Apr 1;21(7):1992-2000. doi: 10.1016/j.bmc.2013.01.020. Epub 2013 Jan 18. Bioorg Med Chem. 2013. PMID: 23395111

4

Design, synthesis and evaluation of peptide inhibitors of Mycobacterium tuberculosis ribonucleotide reductase.

Nurbo J, Roos AK, Muthas D, Wahlström E, Ericsson DJ, Lundstedt T, Unge T, Karlén A. Nurbo J, et al. Among authors: muthas d. J Pept Sci. 2007 Dec;13(12):822-32. doi: 10.1002/psc.906. J Pept Sci. 2007. PMID: 17918768

5

Identification of small peptides mimicking the R2 C-terminus of Mycobacterium tuberculosis ribonucleotide reductase.

Ericsson DJ, Nurbo J, Muthas D, Hertzberg K, Lindeberg G, Karlén A, Unge T. Ericsson DJ, et al. Among authors: muthas d. J Pept Sci. 2010 Mar;16(3):159-64. doi: 10.1002/psc.1214. J Pept Sci. 2010. PMID: 20127854

6

Is it possible to increase hit rates in structure-based virtual screening by pharmacophore filtering? An investigation of the advantages and pitfalls of post-filtering.

Muthas D, Sabnis YA, Lundborg M, Karlén A. Muthas D, et al. J Mol Graph Model. 2008 Jun;26(8):1237-51. doi: 10.1016/j.jmgm.2007.11.005. Epub 2007 Nov 29. J Mol Graph Model. 2008. PMID: 18203638

7

Scope and limitations of Baird's theory on triplet state aromaticity: application to the tuning of singlet-triplet energy gaps in fulvenes.

Ottosson H, Kilså K, Chajara K, Piqueras MC, Crespo R, Kato H, Muthas D. Ottosson H, et al. Among authors: muthas d. Chemistry. 2007;13(24):6998-7005. doi: 10.1002/chem.200700362. Chemistry. 2007. PMID: 17562534

8

DrugPred: a structure-based approach to predict protein druggability developed using an extensive nonredundant data set.

Krasowski A, Muthas D, Sarkar A, Schmitt S, Brenk R. Krasowski A, et al. Among authors: muthas d. J Chem Inf Model. 2011 Nov 28;51(11):2829-42. doi: 10.1021/ci200266d. Epub 2011 Oct 13. J Chem Inf Model. 2011. PMID: 21995295

9

Exploiting Pharmacological Similarity to Identify Safety Concerns - Listen to What the Data Tells You.

Muthas D, Boyer S. Muthas D, et al. Mol Inform. 2013 Jan;32(1):37-45. doi: 10.1002/minf.201200088. Epub 2013 Jan 14. Mol Inform. 2013. PMID: 27481022

10

Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes.

Garside H, Marcoe KF, Chesnut-Speelman J, Foster AJ, Muthas D, Kenna JG, Warrior U, Bowes J, Baumgartner J. Garside H, et al. Among authors: muthas d. Toxicol In Vitro. 2014 Mar;28(2):171-81. doi: 10.1016/j.tiv.2013.10.015. Epub 2013 Nov 1. Toxicol In Vitro. 2014. PMID: 24189122 Free article.

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