γ-Hydroxy-1,N2-propano-2'-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage.
Huang H, Wang H, Voehler MW, Kozekova A, Rizzo CJ, McCullough AK, Lloyd RS, Stone MP.
Huang H, et al.
Chem Res Toxicol. 2011 Jul 18;24(7):1123-33. doi: 10.1021/tx200113n. Epub 2011 May 11.
Chem Res Toxicol. 2011.
PMID: 21561113
Free PMC article.
The structures of the diastereomeric DNA-KWKK conjugates were predicted from potential energy minimization of model structures derived from the refined structure of the fully reduced cross-link [ Huang, H., Kozekov, I. D., Kozekova, A., Rizzo, C. J., McCullough, A., …
The structures of the diastereomeric DNA-KWKK conjugates were predicted from potential energy minimization of model structures derived from …