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A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury.
Prime TA, Blaikie FH, Evans C, Nadtochiy SM, James AM, Dahm CC, Vitturi DA, Patel RP, Hiley CR, Abakumova I, Requejo R, Chouchani ET, Hurd TR, Garvey JF, Taylor CT, Brookes PS, Smith RA, Murphy MP. Prime TA, et al. Among authors: taylor ct. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10764-9. doi: 10.1073/pnas.0903250106. Epub 2009 Jun 15. Proc Natl Acad Sci U S A. 2009. PMID: 19528654 Free PMC article.
PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells.
O'Hagan KA, Cocchiglia S, Zhdanov AV, Tambuwala MM, Cummins EP, Monfared M, Agbor TA, Garvey JF, Papkovsky DB, Taylor CT, Allan BB. O'Hagan KA, et al. Among authors: taylor ct. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2188-93. doi: 10.1073/pnas.0808801106. Epub 2009 Jan 28. Proc Natl Acad Sci U S A. 2009. PMID: 19179292 Free PMC article.
Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.
Scholz CC, Cavadas MA, Tambuwala MM, Hams E, Rodríguez J, von Kriegsheim A, Cotter P, Bruning U, Fallon PG, Cheong A, Cummins EP, Taylor CT. Scholz CC, et al. Among authors: taylor ct. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18490-5. doi: 10.1073/pnas.1309718110. Epub 2013 Oct 21. Proc Natl Acad Sci U S A. 2013. PMID: 24145445 Free PMC article.
Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation.
Campbell EL, Bruyninckx WJ, Kelly CJ, Glover LE, McNamee EN, Bowers BE, Bayless AJ, Scully M, Saeedi BJ, Golden-Mason L, Ehrentraut SF, Curtis VF, Burgess A, Garvey JF, Sorensen A, Nemenoff R, Jedlicka P, Taylor CT, Kominsky DJ, Colgan SP. Campbell EL, et al. Among authors: taylor ct. Immunity. 2014 Jan 16;40(1):66-77. doi: 10.1016/j.immuni.2013.11.020. Epub 2014 Jan 9. Immunity. 2014. PMID: 24412613 Free PMC article.
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.
Cummins EP, Berra E, Comerford KM, Ginouves A, Fitzgerald KT, Seeballuck F, Godson C, Nielsen JE, Moynagh P, Pouyssegur J, Taylor CT. Cummins EP, et al. Among authors: taylor ct. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18154-9. doi: 10.1073/pnas.0602235103. Epub 2006 Nov 17. Proc Natl Acad Sci U S A. 2006. PMID: 17114296 Free PMC article.
306 results