Suomalainen A - Search Results

1

Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks.

Pohjoismäki JL, Goffart S, Tyynismaa H, Willcox S, Ide T, Kang D, Suomalainen A, Karhunen PJ, Griffith JD, Holt IJ, Jacobs HT. Pohjoismäki JL, et al. Among authors: suomalainen a. J Biol Chem. 2009 Aug 7;284(32):21446-57. doi: 10.1074/jbc.M109.016600. Epub 2009 Jun 12. J Biol Chem. 2009. PMID: 19525233 Free PMC article.

2

Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number.

Tyynismaa H, Sembongi H, Bokori-Brown M, Granycome C, Ashley N, Poulton J, Jalanko A, Spelbrink JN, Holt IJ, Suomalainen A. Tyynismaa H, et al. Among authors: suomalainen a. Hum Mol Genet. 2004 Dec 15;13(24):3219-27. doi: 10.1093/hmg/ddh342. Epub 2004 Oct 27. Hum Mol Genet. 2004. PMID: 15509589

3

Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice.

Tyynismaa H, Mjosund KP, Wanrooij S, Lappalainen I, Ylikallio E, Jalanko A, Spelbrink JN, Paetau A, Suomalainen A. Tyynismaa H, et al. Among authors: suomalainen a. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17687-92. doi: 10.1073/pnas.0505551102. Epub 2005 Nov 21. Proc Natl Acad Sci U S A. 2005. PMID: 16301523 Free PMC article.

4

Infantile-onset spinocerebellar ataxia and mitochondrial recessive ataxia syndrome are associated with neuronal complex I defect and mtDNA depletion.

Hakonen AH, Goffart S, Marjavaara S, Paetau A, Cooper H, Mattila K, Lampinen M, Sajantila A, Lönnqvist T, Spelbrink JN, Suomalainen A. Hakonen AH, et al. Among authors: suomalainen a. Hum Mol Genet. 2008 Dec 1;17(23):3822-35. doi: 10.1093/hmg/ddn280. Epub 2008 Sep 5. Hum Mol Genet. 2008. PMID: 18775955

5

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling.

Goffart S, Cooper HM, Tyynismaa H, Wanrooij S, Suomalainen A, Spelbrink JN. Goffart S, et al. Among authors: suomalainen a. Hum Mol Genet. 2009 Jan 15;18(2):328-40. doi: 10.1093/hmg/ddn359. Epub 2008 Oct 29. Hum Mol Genet. 2009. PMID: 18971204 Free PMC article.

6

Mouse models of mitochondrial DNA defects and their relevance for human disease.

Tyynismaa H, Suomalainen A. Tyynismaa H, et al. Among authors: suomalainen a. EMBO Rep. 2009 Feb;10(2):137-43. doi: 10.1038/embor.2008.242. Epub 2009 Jan 16. EMBO Rep. 2009. PMID: 19148224 Free PMC article. Review.

7

A heterozygous truncating mutation in RRM2B causes autosomal-dominant progressive external ophthalmoplegia with multiple mtDNA deletions.

Tyynismaa H, Ylikallio E, Patel M, Molnar MJ, Haller RG, Suomalainen A. Tyynismaa H, et al. Among authors: suomalainen a. Am J Hum Genet. 2009 Aug;85(2):290-5. doi: 10.1016/j.ajhg.2009.07.009. Epub 2009 Aug 6. Am J Hum Genet. 2009. PMID: 19664747 Free PMC article.

8

Ketogenic diet slows down mitochondrial myopathy progression in mice.

Ahola-Erkkilä S, Carroll CJ, Peltola-Mjösund K, Tulkki V, Mattila I, Seppänen-Laakso T, Oresic M, Tyynismaa H, Suomalainen A. Ahola-Erkkilä S, et al. Among authors: suomalainen a. Hum Mol Genet. 2010 May 15;19(10):1974-84. doi: 10.1093/hmg/ddq076. Epub 2010 Feb 17. Hum Mol Genet. 2010. PMID: 20167576

9

Mouse models of mtDNA replication diseases.

Tyynismaa H, Suomalainen A. Tyynismaa H, et al. Among authors: suomalainen a. Methods. 2010 Aug;51(4):405-10. doi: 10.1016/j.ymeth.2010.03.009. Epub 2010 Apr 10. Methods. 2010. PMID: 20385238 Review.

10

High mitochondrial DNA copy number has detrimental effects in mice.

Ylikallio E, Tyynismaa H, Tsutsui H, Ide T, Suomalainen A. Ylikallio E, et al. Among authors: suomalainen a. Hum Mol Genet. 2010 Jul 1;19(13):2695-705. doi: 10.1093/hmg/ddq163. Epub 2010 Apr 22. Hum Mol Genet. 2010. PMID: 20413656

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