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Ribonucleotide reductase as one important target of [Tris(1,10-phenanthroline)lanthanum(III)] trithiocyanate (KP772).
Heffeter P, Popovic-Bijelic A, Saiko P, Dornetshuber R, Jungwirth U, Voevodskaya N, Biglino D, Jakupec MA, Elbling L, Micksche M, Szekeres T, Keppler BK, Gräslund A, Berger W. Heffeter P, et al. Among authors: szekeres t. Curr Cancer Drug Targets. 2009 Aug;9(5):595-607. doi: 10.2174/156800909789056962. Epub 2009 Aug 1. Curr Cancer Drug Targets. 2009. PMID: 19508176 Free PMC article.
Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells.
Saiko P, Ozsvar-Kozma M, Madlener S, Bernhaus A, Lackner A, Grusch M, Horvath Z, Krupitza G, Jaeger W, Ammer K, Fritzer-Szekeres M, Szekeres T. Saiko P, et al. Among authors: szekeres t. Cancer Lett. 2007 Jun 8;250(2):323-8. doi: 10.1016/j.canlet.2006.10.018. Epub 2006 Nov 29. Cancer Lett. 2007. PMID: 17137710
A novel N-hydroxy-N'-aminoguanidine derivative inhibits ribonucleotide reductase activity: Effects in human HL-60 promyelocytic leukemia cells and synergism with arabinofuranosylcytosine (Ara-C).
Saiko P, Graser G, Giessrigl B, Lackner A, Grusch M, Krupitza G, Basu A, Sinha BN, Jayaprakash V, Jaeger W, Fritzer-Szekeres M, Szekeres T. Saiko P, et al. Among authors: szekeres t. Biochem Pharmacol. 2011 Jan 1;81(1):50-9. doi: 10.1016/j.bcp.2010.09.006. Epub 2010 Sep 16. Biochem Pharmacol. 2011. PMID: 20849828
Thiosemicarbazone derivatives, thiazolyl hydrazones, effectively inhibit leukemic tumor cell growth: Down-regulation of ribonucleotide reductase activity and synergism with arabinofuranosylcytosine.
Graser-Loescher G, Schoenhuber A, Ciglenec C, Eberl S, Krupitza G, Mader RM, Jadav SS, Jayaprakash V, Fritzer-Szekeres M, Szekeres T, Saiko P. Graser-Loescher G, et al. Among authors: szekeres t. Food Chem Toxicol. 2017 Oct;108(Pt A):53-62. doi: 10.1016/j.fct.2017.07.029. Epub 2017 Jul 14. Food Chem Toxicol. 2017. PMID: 28716444
209 results