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Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment.
Cheng XW, Murohara T, Kuzuya M, Izawa H, Sasaki T, Obata K, Nagata K, Nishizawa T, Kobayashi M, Yamada T, Kim W, Sato K, Shi GP, Okumura K, Yokota M. Cheng XW, et al. Among authors: obata k. Am J Pathol. 2008 Aug;173(2):358-69. doi: 10.2353/ajpath.2008.071126. Epub 2008 Jun 26. Am J Pathol. 2008. PMID: 18583318 Free PMC article.
Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt.
Kato MF, Shibata R, Obata K, Miyachi M, Yazawa H, Tsuboi K, Yamada T, Nishizawa T, Noda A, Cheng XW, Murate T, Koike Y, Murohara T, Yokota M, Nagata K. Kato MF, et al. Among authors: obata k. J Hypertens. 2008 Aug;26(8):1669-76. doi: 10.1097/HJH.0b013e328302f0f7. J Hypertens. 2008. PMID: 18622247
Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers.
Cheng XW, Okumura K, Kuzuya M, Jin Z, Nagata K, Obata K, Inoue A, Hirashiki A, Takeshita K, Unno K, Harada K, Shi GP, Yokota M, Murohara T. Cheng XW, et al. Among authors: obata k. J Cardiovasc Pharmacol. 2009 Jul;54(1):47-56. doi: 10.1097/FJC.0b013e3181ab371d. J Cardiovasc Pharmacol. 2009. PMID: 19528815 Free PMC article.
Ca(2+) channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats.
Nishizawa T, Cheng XW, Jin Z, Obata K, Nagata K, Hirashiki A, Sasaki T, Noda A, Takeshita K, Izawa H, Shi GP, Kuzuya M, Okumura K, Murohara T. Nishizawa T, et al. Among authors: obata k. J Hypertens. 2010 Jul;28(7):1515-26. doi: 10.1097/HJH.0b013e328339fd3a. J Hypertens. 2010. PMID: 20543715 Free PMC article.
720 results